Simvastatin and Diltiazem Interaction
Drug interaction information between Simvastatin and Diltiazem.
Simvastatin and Diltiazem have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Simvastatin and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem blocks the enzymes that break down simvastatin, causing the drug to stay in your body longer. This can lead to a higher risk of muscle pain or damage.
FDA Label Information
Intervention: For patients taking verapamil, diltiazem, or dronedarone, do not exceed ezetimibe and simvastatin 10 mg/10 mg daily.
Simvastatin Also Interacts With
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
- Ranolazine major
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Theophylline major
- Rifampin moderate
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Simvastatin + Diltiazem?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Simvastatin's 41. In the major band specifically: Simvastatin has 11 (also Verapamil, Cyclosporine, Amiodarone, Dronedarone); Diltiazem has 4 (also Ezetimibe, Ezetimibe/Simvastatin, Theophylline).
What mechanism field is on file for Simvastatin and Diltiazem?
Diltiazem blocks the enzymes that break down simvastatin, causing the drug to stay in your body longer. This can lead to a higher risk of muscle pain or damage.
Simvastatin carries more major-labeled pairs than Diltiazem
SPL source-record counts only. This page's band is major · classes on file: Simvastatin (HMG-CoA Reductase Inhibitor (Statin)); Diltiazem (Calcium Channel Blocker).
Simvastatin has 11 major-labeled pairs vs Diltiazem's 4.
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Verapamil
- Cyclosporine
- Amiodarone
- Dronedarone
4 major · 7 moderate · 35 minor · 46 total
- Other major peers for Diltiazem
- Ezetimibe
- Ezetimibe/Simvastatin
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.