Escitalopram and Carbamazepine Interaction
Drug interaction information between Escitalopram and Carbamazepine.
Escitalopram and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Escitalopram and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine makes your liver work faster to break down escitalopram, which can lower the amount of medicine in your system.
FDA Label Information
Carbamazepine Clinical Impact: Combined administration of racemic citalopram (40 mg/day for 14 days) and carbamazepine (titrated to 400 mg/day for 35 days) did not significantly affect the pharmacokinetics of carbamazepine, a CYP3A4 substrate. Intervention: Although trough citalopram plasma levels were unaffected, given the enzyme-inducing properties of carbamazepine, the possibility that carbamazepine might increase the clearance of escitalopram should be considered if the two drugs are coadministered.
Escitalopram Also Interacts With
- Citalopram major
- Linezolid major
- Pimozide major
- Aspirin moderate
- Warfarin moderate
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Escitalopram + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Escitalopram's 12. In the minor band specifically: Escitalopram has 7 (also Buspirone, Sumatriptan, Lithium, Desipramine); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Escitalopram and Carbamazepine?
Carbamazepine makes your liver work faster to break down escitalopram, which can lower the amount of medicine in your system.
Carbamazepine's labeled portfolio outnumbers Escitalopram
SPL source-record counts only. This page's band is minor · classes on file: Escitalopram (Selective Serotonin Reuptake Inhibitor (SSRI)); Carbamazepine (Anticonvulsant).
3 major · 2 moderate · 7 minor · 12 total
- Other minor peers for Escitalopram
- Buspirone
- Sumatriptan
- Lithium
- Desipramine
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.