Escitalopram and Aspirin Interaction
Drug interaction information between Escitalopram and Aspirin.
Escitalopram and Aspirin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Escitalopram and Aspirin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Escitalopram can interfere with how blood cells stick together, and aspirin also thins the blood. Combining them makes it much more likely that you will experience bleeding or bruising.
What To Do
Use this combination with caution and tell your doctor if you notice any unusual bleeding. They may need to monitor you more frequently.
FDA Label Information
If serotonin syndrome occurs, consider discontinuation of escitalopram and/or concomitant serotonergic drugs [ see Warnings and Precautions(5.2) ] Drugs That Interfere With Hemostasis (NSAIDs, Aspirin, Warfarin, etc.) Clinical Impact: Concomitant use of escitalopram and an antiplatelet or anticoagulant may potentiate the risk of bleeding. Concomitant use with SSRIs, SNRIs or Tryptophan is not recommended ( 7 ) Use caution when concomitant use with drugs that affect Hemostasis (NSAIDs, Aspirin, Warfarin) ( 7 )
Escitalopram Also Interacts With
- Citalopram major
- Linezolid major
- Pimozide major
- Warfarin moderate
- Buspirone minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
Can I take Escitalopram and Aspirin together?
This is a moderate interaction. Use this combination with caution and tell your doctor if you notice any unusual bleeding. They may need to monitor you more frequently.
How serious is the interaction between Escitalopram and Aspirin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Escitalopram and Aspirin interact?
Escitalopram can interfere with how blood cells stick together, and aspirin also thins the blood. Combining them makes it much more likely that you will experience bleeding or bruising.
Understanding the Escitalopram and Aspirin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Escitalopram belongs to the Selective Serotonin Reuptake Inhibitor (SSRI) class and Aspirin belongs to the Antiplatelet / NSAID class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Escitalopram can interfere with how blood cells stick together, and aspirin also thins the blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Escitalopram has 12 total documented interactions on file in this dataset, and Aspirin has 47. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use this combination with caution and tell your doctor if you notice any unusual bleeding. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Escitalopram or Aspirin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.