Escitalopram and Aspirin Interaction
Drug interaction information between Escitalopram and Aspirin.
Escitalopram and Aspirin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Escitalopram and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Escitalopram can interfere with how blood cells stick together, and aspirin also thins the blood. Combining them makes it much more likely that you will experience bleeding or bruising.
FDA Label Information
If serotonin syndrome occurs, consider discontinuation of escitalopram and/or concomitant serotonergic drugs [ see Warnings and Precautions(5.2) ] Drugs That Interfere With Hemostasis (NSAIDs, Aspirin, Warfarin, etc.) Clinical Impact: Concomitant use of escitalopram and an antiplatelet or anticoagulant may potentiate the risk of bleeding. Concomitant use with SSRIs, SNRIs or Tryptophan is not recommended ( 7 ) Use caution when concomitant use with drugs that affect Hemostasis (NSAIDs, Aspirin, Warfarin) ( 7 )
Escitalopram Also Interacts With
- Citalopram major
- Linezolid major
- Pimozide major
- Warfarin moderate
- Buspirone minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Escitalopram + Aspirin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Escitalopram's 12. In the moderate band specifically: Escitalopram has 2 (also Warfarin); Aspirin has 12 (also Alendronate, Apixaban, Desvenlafaxine, Dexamethasone).
What mechanism field is on file for Escitalopram and Aspirin?
Escitalopram can interfere with how blood cells stick together, and aspirin also thins the blood. Combining them makes it much more likely that you will experience bleeding or bruising.
Aspirin's labeled portfolio outnumbers Escitalopram
SPL source-record counts only. This page's band is moderate · classes on file: Escitalopram (Selective Serotonin Reuptake Inhibitor (SSRI)); Aspirin (Antiplatelet / NSAID).
3 major · 2 moderate · 7 minor · 12 total
- Other moderate peers for Escitalopram
- Warfarin
3 major · 12 moderate · 32 minor · 47 total
- Other moderate peers for Aspirin
- Alendronate
- Apixaban
- Desvenlafaxine
- Dexamethasone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.