Escitalopram and Buspirone Interaction
Drug interaction information between Escitalopram and Buspirone.
Escitalopram and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Escitalopram and Buspirone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase the level of a brain chemical called serotonin, which can cause a dangerous buildup if it gets too high.
FDA Label Information
Other Serotonergic Drugs Clinical Impact: Concomitant use of escitalopram and other serotonergic drugs (including other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St.
Escitalopram Also Interacts With
- Citalopram major
- Linezolid major
- Pimozide major
- Aspirin moderate
- Warfarin moderate
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Escitalopram + Buspirone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buspirone has 17 labeled pairs on file vs Escitalopram's 12. In the minor band specifically: Escitalopram has 7 (also Sumatriptan, Carbamazepine, Lithium, Desipramine); Buspirone has 15 (also Citalopram, Darunavir, Desvenlafaxine, Diltiazem).
What mechanism field is on file for Escitalopram and Buspirone?
Both drugs increase the level of a brain chemical called serotonin, which can cause a dangerous buildup if it gets too high.
Escitalopram carries more major-labeled pairs than Buspirone
SPL source-record counts only. This page's band is minor · classes on file: Escitalopram (Selective Serotonin Reuptake Inhibitor (SSRI)); Buspirone (Azapirone Anxiolytic).
Escitalopram has 3 major-labeled pairs vs Buspirone's 0. This page itself is in the minor band, not the major band.
3 major · 2 moderate · 7 minor · 12 total
- Other minor peers for Escitalopram
- Sumatriptan
- Carbamazepine
- Lithium
- Desipramine
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Desvenlafaxine
- Diltiazem
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.