What the FDA labels say about taking them together
Escitalopram and pimozide
Escitalopram's FDA label of October 1, 2023 names pimozide in its contraindications section, and pimozide's label names escitalopram too. The escitalopram label: “Concomitant use of racemic citalopram with pimozide increases plasma concentrations of pimozide, a drug with a narrow therapeutic index, and may increase the risk of QT prolongation and/or ventricular arrhythmias …”
Check it at the source: the escitalopram FDA label on DailyMed (effective October 1, 2023, Allergan, Inc.); the pimozide FDA label on DailyMed (effective August 12, 2026, Par Health USA, LLC).
What does the escitalopram label say about pimozide?
Escitalopram label, contraindicationsStarting Lexapro in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is also contraindicated because of an increased risk of serotonin syndrome [ see Dosage and Administration ( 2.6 ) and Warnings and Precautions ( 5.2 ) ]. taking pimozide [see Drug Interactions ( 7 ) ]. with a hypersensitivity to escitalopram or citalopram or any of the inactive ingredients in Lexapro.
Escitalopram label, drug interactionsPimozide Clinical Impact: Concomitant use of racemic citalopram with pimozide increases plasma concentrations of pimozide, a drug with a narrow therapeutic index, and may increase the risk of QT prolongation and/or ventricular arrhythmias compared to use of racemic citalopram alone. Intervention: Lexapro is contraindicated in patients taking pimozide [see Contraindications ()].
Escitalopram label (Almatica Pharma LLC, August 31, 2025), contraindicationsTaking pimozide because of the risk of QT prolongation [see Drug Interactions ( 7 )].
Escitalopram label (Almatica Pharma LLC, August 31, 2025), drug interactionsPimozide Prevention or Management Escitalopram Capsules are contraindicated in patients taking pimozide [see Contraindications ( 4 )].
Source: FDA drug label (Escitalopram, NDA219130), Almatica Pharma LLC, effective August 31, 2025 (SPL set c0401570-a3b0-bef2-7365-c23dc952b8b6), via openFDA
Source: FDA drug label (Lexapro), NDA021323 (Abbvie), as published by Allergan, Inc., effective October 1, 2023 (SPL set 13bb8267-1cab-43e5-acae-55a4d957630a), via openFDA; the full label on DailyMed
What does the pimozide label say about escitalopram?
Pimozide label, contraindicationsConcomitant use in patients taking Celexa or Lexapro is contraindicated (see PRECAUTIONS - DRUG INTERACTIONS - Pimozide and Celexa ).
Source: FDA drug label (Pimozide), Par Health USA, LLC, effective August 12, 2026 (SPL set 70b079e2-a1f7-4a93-8685-d60a4d7c1280), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Escitalopram | Pimozide | |
|---|---|---|
| Labeled for | Depression, Anxiety | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0632 per tablet 20 mg tablet | $1.23 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once