Escitalopram and Desipramine Interaction
Drug interaction information between Escitalopram and Desipramine.
Escitalopram and Desipramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Escitalopram and Desipramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Escitalopram slows down how quickly your body gets rid of desipramine, which can cause the levels of desipramine to build up.
FDA Label Information
Drugs Metabolized by CYP2D6 Clinical Impact: Coadministration of escitalopram (20 mg/day for 21 days) with the tricyclic antidepressant desipramine (single dose of 50 mg), a substrate for CYP2D6, resulted in a 40% increase in C max and a 100% increase in AUC of desipramine.
Escitalopram Also Interacts With
- Citalopram major
- Linezolid major
- Pimozide major
- Aspirin moderate
- Warfarin moderate
Desipramine Also Interacts With
- Atomoxetine minor
- Bupropion minor
- Darunavir minor
- Desvenlafaxine minor
- Dopamine minor
Frequently Asked Questions
What SPL severity band is on file for Escitalopram + Desipramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Desipramine has 18 labeled pairs on file vs Escitalopram's 12. In the minor band specifically: Escitalopram has 7 (also Buspirone, Sumatriptan, Carbamazepine, Lithium); Desipramine has 18 (also Atomoxetine, Bupropion, Darunavir, Desvenlafaxine).
What mechanism field is on file for Escitalopram and Desipramine?
Escitalopram slows down how quickly your body gets rid of desipramine, which can cause the levels of desipramine to build up.
Escitalopram carries more major-labeled pairs than Desipramine
SPL source-record counts only. This page's band is minor · classes on file: Escitalopram (Selective Serotonin Reuptake Inhibitor (SSRI)); Desipramine (Tricyclic Antidepressant (TCA)).
Escitalopram has 3 major-labeled pairs vs Desipramine's 0. This page itself is in the minor band, not the major band.
3 major · 2 moderate · 7 minor · 12 total
- Other minor peers for Escitalopram
- Buspirone
- Sumatriptan
- Carbamazepine
- Lithium
0 major · 0 moderate · 18 minor · 18 total
- Other minor peers for Desipramine
- Atomoxetine
- Bupropion
- Darunavir
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.