Escitalopram and Warfarin Interaction
Drug interaction information between Escitalopram and Warfarin.
Escitalopram and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Escitalopram and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination increases your risk of bleeding because both drugs affect how your blood clots. Escitalopram can also change how your body responds to the blood thinner.
FDA Label Information
If serotonin syndrome occurs, consider discontinuation of escitalopram and/or concomitant serotonergic drugs [ see Warnings and Precautions(5.2) ] Drugs That Interfere With Hemostasis (NSAIDs, Aspirin, Warfarin, etc.) Clinical Impact: Concomitant use of escitalopram and an antiplatelet or anticoagulant may potentiate the risk of bleeding. For patients taking warfarin, carefully monitor the internationalnormalized ratio [ see Warnings and Precautions (5.7) ]. Concomitant use with SSRIs, SNRIs or Tryptophan is not recommended ( 7 ) Use caution when concomitant use with drugs that affect...
Escitalopram Also Interacts With
- Citalopram major
- Linezolid major
- Pimozide major
- Aspirin moderate
- Buspirone minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Escitalopram + Warfarin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Escitalopram's 12. In the moderate band specifically: Escitalopram has 2 (also Aspirin); Warfarin has 28 (also Ibuprofen, Aspirin, Diclofenac, Desvenlafaxine).
What mechanism field is on file for Escitalopram and Warfarin?
This combination increases your risk of bleeding because both drugs affect how your blood clots. Escitalopram can also change how your body responds to the blood thinner.
Escitalopram carries more major-labeled pairs than Warfarin
SPL source-record counts only. This page's band is moderate · classes on file: Escitalopram (Selective Serotonin Reuptake Inhibitor (SSRI)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Escitalopram has 3 major-labeled pairs vs Warfarin's 2. This page itself is in the moderate band, not the major band.
3 major · 2 moderate · 7 minor · 12 total
- Other moderate peers for Escitalopram
- Aspirin
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Diclofenac
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.