digoxin vs nicardipine
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Side-by-side comparison of digoxin and nicardipine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Digoxin Some calcium blockers may increase the concentration of digitalis preparations in the blood. Nicardipine hydrochloride capsules usually do not alter the plasma levels of digoxin; however, serum digoxin levels should be evaluated after concomitant therapy with nicardipine hydrochloride capsules are initiated.
Lanoxin
Cardene
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Nicardipine is a drug that helps to lower blood pressure and treat chest pain. It belongs to a class of drugs called calcium channel blockers.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Nicardipine treats chronic stable angina, which is chest pain that happens when you exert yourself. It can be used alone or with beta-blockers to manage this condition. Nicardipine also treats high blood pressure, and it can be used alone or with other blood pressure medications.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Nicardipine works by blocking calcium from entering certain cells in your heart and blood vessels. This helps to relax and widen your blood vessels, which lowers blood pressure. It also reduces the workload on your heart, which can help to relieve chest pain.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Swelling in your feet or ankles
- • Dizziness
- • Headache
- • Weakness
- • Flushing (redness of the skin)
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
- Acute Kidney Injury 226
- Premature Baby 205
- Foetal Exposure During Pregnancy 194
- Maternal Exposure During Pregnancy 180
- Drug Interaction 167
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
If you have advanced aortic stenosis, you should not take this medication. Lowering blood pressure in this case could worsen oxygen balance to the heart. Use caution if you have congestive heart failure.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if nicardipine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking nicardipine during pregnancy or while breastfeeding.
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How to Read This digoxin vs nicardipine Comparison
digoxin is classified in the Cardiac Glycoside drug class, while nicardipine sits within the Calcium Channel Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,407 submissions while nicardipine has 972. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to nicardipine may cause digoxin to build up in your bloodstream by changing how your body handles the drug.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for digoxin or nicardipine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.