amlodipine vs cyclosporine
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Side-by-side comparison of amlodipine and cyclosporine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Immunosuppressants Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when co-administered. Frequent monitoring of trough blood levels of cyclosporine and tacrolimus is recommended and adjust the dose when appropriate [see CLINICAL PHARMACOLOGY ( 12.3 )] .
Norvasc
Neoral, Sandimmune, Restasis
Amlodipine (Norvasc) is a drug that lowers blood pressure and treats chest pain. It belongs to a class of drugs called calcium channel blockers.
Vevye eye drops contain cyclosporine. They help treat the signs and symptoms of dry eye disease.
This medicine treats high blood pressure (hypertension). Lowering blood pressure reduces the risk of strokes and heart attacks. Amlodipine also treats chest pain (angina) caused by coronary artery disease, including chronic stable angina and vasospastic angina.
Vevye treats the signs and symptoms of dry eye disease. Dry eye can cause discomfort, stinging, and blurred vision. This medicine can help reduce these symptoms.
Amlodipine blocks calcium from entering heart and blood vessel cells. This relaxes and widens blood vessels, making it easier for blood to flow. As a result, the heart does not have to work as hard, which lowers blood pressure and reduces chest pain.
Vevye contains cyclosporine, which is an immunosuppressant. It works by decreasing inflammation in the eyes. This helps your eyes make more tears.
- • Swelling in your ankles or feet
- • Dizziness
- • Flushing (redness of the face)
- • Palpitations (feeling your heart beat rapidly or irregularly)
- • Fatigue (feeling tired)
- • Irritation where the drops are applied (8%)
- Fatigue 15,697
- Diarrhoea 14,039
- Nausea 13,425
- Dyspnoea 13,218
- Dizziness 10,671
- Eye Irritation 7,786
- Pyrexia 4,064
- Eye Pain 3,808
- Nausea 3,623
- Diarrhoea 3,562
Amlodipine may cause low blood pressure, especially if you have severe aortic stenosis. Some people with severe heart disease may experience worsening chest pain or a heart attack when starting or increasing the dose of amlodipine. If you have severe liver problems, your doctor will increase your dose slowly.
To avoid eye injury or contamination, do not touch the bottle tip to your eye or any other surface. Do not use Vevye while wearing contact lenses. If you wear contacts, remove them before using the drops. You can put them back in 15 minutes after using Vevye.
Tell your doctor if you are pregnant or plan to become pregnant. High blood pressure during pregnancy can harm both the mother and the baby. Amlodipine passes into breast milk, but no harmful effects on the breastfed infant have been seen.
It is not known if Vevye will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Cyclosporine can pass into breast milk after being taken orally, but it is unknown if it passes into breast milk from eye drops. Talk to your doctor if you are breastfeeding.
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How to Read This amlodipine vs cyclosporine Comparison
amlodipine is classified in the Calcium Channel Blocker drug class, while cyclosporine sits within the Calcineurin Inhibitor (Immunosuppressant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amlodipine has 67,050 submissions while cyclosporine has 22,843. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to amlodipine can increase the amount of cyclosporine that stays in your body. this could lead to higher levels of the drug than your body needs.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for amlodipine or cyclosporine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.