Amiodarone and Clonidine Interaction
Drug interaction information between Amiodarone and Clonidine.
Amiodarone and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amiodarone and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs slow down the heart rate. Taking them together can make the heart beat too slowly or cause it to stop momentarily.
FDA Label Information
Negative Chronotropes digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradine Potentiates the electrophysiologic and hemodynamic effects of amiodarone, resulting in bradycardia, sinus arrest, and AV block.
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Amiodarone + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Clonidine's 29. In the minor band specifically: Amiodarone has 29 (also Atorvastatin, Diltiazem, Verapamil, Cyclosporine); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Amiodarone and Clonidine?
Both drugs slow down the heart rate. Taking them together can make the heart beat too slowly or cause it to stop momentarily.
Amiodarone carries more major-labeled pairs than Clonidine
SPL source-record counts only. This page's band is minor · classes on file: Amiodarone (Class III Antiarrhythmic); Clonidine (Central Alpha-2 Agonist).
Amiodarone has 4 major-labeled pairs vs Clonidine's 0. This page itself is in the minor band, not the major band.
4 major · 9 moderate · 29 minor · 42 total
- Other minor peers for Amiodarone
- Atorvastatin
- Diltiazem
- Verapamil
- Cyclosporine
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.