Citalopram and Sertraline Interaction
Drug interaction information between Citalopram and Sertraline.
Citalopram and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Citalopram and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs belong to the same class and both raise serotonin, which can cause levels to become higher than intended.
FDA Label Information
If concomitant treatment with sumatriptan and an SSRI (e.g., citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) is clinically warranted, appropriate observation of the patient is advised.
Citalopram Also Interacts With
- Linezolid major
- Pimozide major
- Escitalopram major
- Warfarin moderate
- Phenelzine moderate
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Citalopram + Sertraline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Citalopram's 9. In the minor band specifically: Citalopram has 4 (also Buspirone, Lithium, Carbamazepine); Sertraline has 31 (also Fluoxetine, Paroxetine, Atenolol, Sumatriptan).
What mechanism field is on file for Citalopram and Sertraline?
These two drugs belong to the same class and both raise serotonin, which can cause levels to become higher than intended.
Citalopram carries more major-labeled pairs than Sertraline
SPL source-record counts only. This page's band is minor · classes on file: Citalopram (Selective Serotonin Reuptake Inhibitor (SSRI)); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
Citalopram has 3 major-labeled pairs vs Sertraline's 1. This page itself is in the minor band, not the major band.
3 major · 2 moderate · 4 minor · 9 total
- Other minor peers for Citalopram
- Buspirone
- Lithium
- Carbamazepine
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Paroxetine
- Atenolol
- Sumatriptan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.