Citalopram and Lithium Interaction
Drug interaction information between Citalopram and Lithium.
Citalopram and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Citalopram and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase the amount of a chemical called serotonin in your brain. Taking them together can cause serotonin levels to become dangerously high.
FDA Label Information
Other Serotonergic Drugs Clinical Impact: Concomitant use of citalopram and other serotonergic drugs (including other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St.
Citalopram Also Interacts With
- Linezolid major
- Pimozide major
- Escitalopram major
- Warfarin moderate
- Phenelzine moderate
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Citalopram + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Citalopram's 9. In the minor band specifically: Citalopram has 4 (also Buspirone, Carbamazepine, Sertraline); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Citalopram and Lithium?
Both drugs increase the amount of a chemical called serotonin in your brain. Taking them together can cause serotonin levels to become dangerously high.
Citalopram carries more major-labeled pairs than Lithium
SPL source-record counts only. This page's band is minor · classes on file: Citalopram (Selective Serotonin Reuptake Inhibitor (SSRI)); Lithium (Mood Stabilizer).
Citalopram has 3 major-labeled pairs vs Lithium's 2. This page itself is in the minor band, not the major band.
3 major · 2 moderate · 4 minor · 9 total
- Other minor peers for Citalopram
- Buspirone
- Carbamazepine
- Sertraline
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.