Citalopram and Linezolid Interaction
Drug interaction information between Citalopram and Linezolid.
Citalopram and Linezolid have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Citalopram and Linezolid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Linezolid acts like a special type of medicine called an MAO inhibitor, which can cause a dangerous buildup of a brain chemical called serotonin when mixed with citalopram.
FDA Label Information
Intervention Citalopram is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Dosage and Administration (2.5) , Contraindications (4) , Warnings and Precautions (5.3) ] .
Citalopram Also Interacts With
- Pimozide major
- Escitalopram major
- Warfarin moderate
- Phenelzine moderate
- Buspirone minor
Linezolid Also Interacts With
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
- Tranylcypromine major
Frequently Asked Questions
What SPL severity band is on file for Citalopram + Linezolid?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Linezolid has 29 labeled pairs on file vs Citalopram's 9. In the major band specifically: Citalopram has 3 (also Pimozide, Escitalopram); Linezolid has 8 (also Escitalopram, Mirtazapine, Paroxetine, Safinamide).
What mechanism field is on file for Citalopram and Linezolid?
Linezolid acts like a special type of medicine called an MAO inhibitor, which can cause a dangerous buildup of a brain chemical called serotonin when mixed with citalopram.
Linezolid carries more major-labeled pairs than Citalopram
SPL source-record counts only. This page's band is major · classes on file: Citalopram (Selective Serotonin Reuptake Inhibitor (SSRI)); Linezolid (Oxazolidinone Antibiotic).
Linezolid has 8 major-labeled pairs vs Citalopram's 3.
3 major · 2 moderate · 4 minor · 9 total
- Other major peers for Citalopram
- Pimozide
- Escitalopram
8 major · 3 moderate · 18 minor · 29 total
- Other major peers for Linezolid
- Escitalopram
- Mirtazapine
- Paroxetine
- Safinamide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.