Chlorpromazine and Carbamazepine Interaction
Drug interaction information between Chlorpromazine and Carbamazepine.
Chlorpromazine and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Chlorpromazine and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Mixing these two liquid medicines together creates a solid, rubbery substance that the body cannot use.
FDA Label Information
Drug Interactions There has been a report of a patient who passed an orange rubbery precipitate in his stool the day after ingesting carbamazepine suspension immediately followed by Thorazine solution. Subsequent testing has shown that mixing carbamazepine suspension and chlorpromazine solution (both generic and brand name) as well as carbamazepine suspension and liquid Mellaril, resulted in the occurrence of this precipitate.
Chlorpromazine Also Interacts With
- Desmopressin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
- Zolpidem moderate
- Clozapine minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Chlorpromazine + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Chlorpromazine's 11. In the minor band specifically: Chlorpromazine has 7 (also Clozapine, Fluoxetine, Meperidine, Pimozide); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Chlorpromazine and Carbamazepine?
Mixing these two liquid medicines together creates a solid, rubbery substance that the body cannot use.
Carbamazepine carries more major-labeled pairs than Chlorpromazine
SPL source-record counts only. This page's band is minor · classes on file: Chlorpromazine (Typical Antipsychotic (Phenothiazine)); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Chlorpromazine's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Chlorpromazine
- Clozapine
- Fluoxetine
- Meperidine
- Pimozide
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.