Chlorpromazine and Tranylcypromine Interaction
Drug interaction information between Chlorpromazine and Tranylcypromine.
Chlorpromazine and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Chlorpromazine and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs can interact to cause dangerously high blood pressure or a life-threatening reaction involving too much serotonin in the brain. They both impact the way your body regulates mood and blood vessel health.
FDA Label Information
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Chlorpromazine Also Interacts With
- Desmopressin moderate
- Tetrabenazine moderate
- Zolpidem moderate
- Carbamazepine minor
- Clozapine minor
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
What SPL severity band is on file for Chlorpromazine + Tranylcypromine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Chlorpromazine's 11. In the moderate band specifically: Chlorpromazine has 4 (also Desmopressin, Tetrabenazine, Zolpidem); Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Lithium).
What mechanism field is on file for Chlorpromazine and Tranylcypromine?
These drugs can interact to cause dangerously high blood pressure or a life-threatening reaction involving too much serotonin in the brain. They both impact the way your body regulates mood and blood vessel health.
Tranylcypromine carries more major-labeled pairs than Chlorpromazine
SPL source-record counts only. This page's band is moderate · classes on file: Chlorpromazine (Typical Antipsychotic (Phenothiazine)); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Chlorpromazine's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Chlorpromazine
- Desmopressin
- Tetrabenazine
- Zolpidem
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.