Chlorpromazine and Desmopressin Interaction
Drug interaction information between Chlorpromazine and Desmopressin.
Chlorpromazine and Desmopressin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Chlorpromazine and Desmopressin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Chlorpromazine can make desmopressin more powerful, making it harder for your body to release water. This increases the risk of developing low sodium levels in your bloodstream.
FDA Label Information
tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, NSAIDs, lamotrigine and carbamazepine) should be performed with caution.
Chlorpromazine Also Interacts With
- Tetrabenazine moderate
- Tranylcypromine moderate
- Zolpidem moderate
- Carbamazepine minor
- Clozapine minor
Desmopressin Also Interacts With
- Lamotrigine moderate
- Carbamazepine moderate
Frequently Asked Questions
What SPL severity band is on file for Chlorpromazine + Desmopressin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Chlorpromazine has 11 labeled pairs on file vs Desmopressin's 3. In the moderate band specifically: Chlorpromazine has 4 (also Tetrabenazine, Tranylcypromine, Zolpidem); Desmopressin has 3 (also Lamotrigine, Carbamazepine).
What mechanism field is on file for Chlorpromazine and Desmopressin?
Chlorpromazine can make desmopressin more powerful, making it harder for your body to release water. This increases the risk of developing low sodium levels in your bloodstream.
Chlorpromazine's labeled portfolio outnumbers Desmopressin
SPL source-record counts only. This page's band is moderate · classes on file: Chlorpromazine (Typical Antipsychotic (Phenothiazine)); Desmopressin (Vasopressin Analog).
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Chlorpromazine
- Tetrabenazine
- Tranylcypromine
- Zolpidem
0 major · 3 moderate · 0 minor · 3 total
- Other moderate peers for Desmopressin
- Lamotrigine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.