Chlorpromazine and Fluoxetine Interaction
Drug interaction information between Chlorpromazine and Fluoxetine.
Chlorpromazine and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Chlorpromazine and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can interfere with your heart's electrical activity and cause an abnormal heart rhythm.
FDA Label Information
These include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); Class 1A antiarrhythmic medications (e.g., quinidine, procainamide); Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus).
Chlorpromazine Also Interacts With
- Desmopressin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
- Zolpidem moderate
- Carbamazepine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Chlorpromazine + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Chlorpromazine's 11. In the minor band specifically: Chlorpromazine has 7 (also Carbamazepine, Clozapine, Meperidine, Pimozide); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Chlorpromazine and Fluoxetine?
Combining these drugs can interfere with your heart's electrical activity and cause an abnormal heart rhythm.
Fluoxetine carries more major-labeled pairs than Chlorpromazine
SPL source-record counts only. This page's band is minor · classes on file: Chlorpromazine (Typical Antipsychotic (Phenothiazine)); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Chlorpromazine's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Chlorpromazine
- Carbamazepine
- Clozapine
- Meperidine
- Pimozide
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.