Chlorpromazine and Meperidine Interaction
Drug interaction information between Chlorpromazine and Meperidine.
Chlorpromazine and Meperidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Chlorpromazine and Meperidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Chlorpromazine is used to help manage high blood pressure and high body temperature that can occur during a severe reaction to meperidine.
FDA Label Information
Intravenous hydrocortisone or prednisolone have been used to treat severe reactions, with the addition of intravenous chlorpromazine in those cases exhibiting hypertension and hyperpyrexia.
Chlorpromazine Also Interacts With
- Desmopressin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
- Zolpidem moderate
- Carbamazepine minor
Meperidine Also Interacts With
- Safinamide major
- Rasagiline moderate
- Tranylcypromine moderate
- Gabapentin minor
- Trazodone minor
Frequently Asked Questions
What SPL severity band is on file for Chlorpromazine + Meperidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Meperidine has 31 labeled pairs on file vs Chlorpromazine's 11. In the minor band specifically: Chlorpromazine has 7 (also Carbamazepine, Clozapine, Fluoxetine, Pimozide); Meperidine has 28 (also Gabapentin, Trazodone, Tramadol, Cyclobenzaprine).
What mechanism field is on file for Chlorpromazine and Meperidine?
Chlorpromazine is used to help manage high blood pressure and high body temperature that can occur during a severe reaction to meperidine.
Meperidine carries more major-labeled pairs than Chlorpromazine
SPL source-record counts only. This page's band is minor · classes on file: Chlorpromazine (Typical Antipsychotic (Phenothiazine)); Meperidine (Opioid Analgesic).
Meperidine has 1 major-labeled pair vs Chlorpromazine's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Chlorpromazine
- Carbamazepine
- Clozapine
- Fluoxetine
- Pimozide
1 major · 2 moderate · 28 minor · 31 total
- Other minor peers for Meperidine
- Gabapentin
- Trazodone
- Tramadol
- Cyclobenzaprine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.