Imipramine and Propafenone Interaction
Drug interaction information between Imipramine and Propafenone.
Imipramine and Propafenone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Imipramine and Propafenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medicines use the same pathway in the liver to be broken down, which can lead to higher levels of the drugs in your body.
FDA Label Information
The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide).
Imipramine Also Interacts With
- Epinephrine moderate
- Norepinephrine moderate
- Zolpidem moderate
- Sertraline minor
- Paroxetine minor
Propafenone Also Interacts With
- Nirmatrelvir/Ritonavir major
- Amiodarone moderate
- Fluoxetine moderate
- Nebivolol moderate
- Ketoconazole minor
Frequently Asked Questions
What SPL severity band is on file for Imipramine + Propafenone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propafenone has 26 labeled pairs on file vs Imipramine's 20. In the minor band specifically: Imipramine has 17 (also Sertraline, Paroxetine, Flecainide, Atropine); Propafenone has 22 (also Ketoconazole, Erythromycin, Desipramine, Cimetidine).
What mechanism field is on file for Imipramine and Propafenone?
These two medicines use the same pathway in the liver to be broken down, which can lead to higher levels of the drugs in your body.
Propafenone carries more major-labeled pairs than Imipramine
SPL source-record counts only. This page's band is minor · classes on file: Imipramine (Tricyclic Antidepressant (TCA)); Propafenone (Class IC Antiarrhythmic).
Propafenone has 1 major-labeled pair vs Imipramine's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 17 minor · 20 total
- Other minor peers for Imipramine
- Sertraline
- Paroxetine
- Flecainide
- Atropine
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Propafenone
- Ketoconazole
- Erythromycin
- Desipramine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.