What the FDA labels say about taking them together
Flecainide and imipramine
Imipramine's FDA label of August 11, 2026 names flecainide in its drug interactions section; the flecainide label PlainMeds reads does not name imipramine.
Check it at the source: the flecainide FDA label on DailyMed (effective June 11, 2026, Amneal Pharmaceuticals of New York LLC); the imipramine FDA label on DailyMed (effective August 11, 2026, Leading Pharma, LLC).
What does the flecainide label say about imipramine?
Flecainide's label (effective June 11, 2026) does not name imipramine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Flecainide Acetate), Amneal Pharmaceuticals of New York LLC, effective June 11, 2026 (SPL set ee9595d5-08a1-4529-9215-ddc3c7f929c4), via openFDA; the full label on DailyMed
What does the imipramine label say about flecainide?
Imipramine label, drug interactionsThe drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide).
Source: FDA drug label (Imipramine Hydrochloride), Leading Pharma, LLC, effective August 11, 2026 (SPL set 490263ce-b4d2-428a-87da-fcd07f85499a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Flecainide | Imipramine | |
|---|---|---|
| Labeled for | n/a | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.171 per tablet 100 mg tablet | $0.0698 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once