Imipramine and Sertraline Interaction
Drug interaction information between Imipramine and Sertraline.
Imipramine and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Imipramine and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sertraline interferes with how your liver processes imipramine, which can lead to higher levels of imipramine in your blood.
FDA Label Information
While all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition.
Imipramine Also Interacts With
- Epinephrine moderate
- Norepinephrine moderate
- Zolpidem moderate
- Paroxetine minor
- Flecainide minor
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Frequently Asked Questions
What SPL severity band is on file for Imipramine + Sertraline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Imipramine's 20. In the minor band specifically: Imipramine has 17 (also Paroxetine, Flecainide, Propafenone, Atropine); Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Atenolol).
What mechanism field is on file for Imipramine and Sertraline?
Sertraline interferes with how your liver processes imipramine, which can lead to higher levels of imipramine in your blood.
Sertraline carries more major-labeled pairs than Imipramine
SPL source-record counts only. This page's band is minor · classes on file: Imipramine (Tricyclic Antidepressant (TCA)); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
Sertraline has 1 major-labeled pair vs Imipramine's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 17 minor · 20 total
- Other minor peers for Imipramine
- Paroxetine
- Flecainide
- Propafenone
- Atropine
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Atenolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.