What the FDA labels say about taking them together
Imipramine and sertraline
Imipramine's FDA label of August 11, 2026 names sertraline in its drug interactions section; sertraline's label does not name imipramine itself but warns about its class (Tricyclic antidepressants). The imipramine label: “While all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition.”
Check it at the source: the imipramine FDA label on DailyMed (effective August 11, 2026, Leading Pharma, LLC); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the imipramine label say about sertraline?
Imipramine label, drug interactionsWhile all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition.
Source: FDA drug label (Imipramine Hydrochloride), Leading Pharma, LLC, effective August 11, 2026 (SPL set 490263ce-b4d2-428a-87da-fcd07f85499a), via openFDA; the full label on DailyMed
What does the sertraline label say about imipramine?
Sertraline's label does not name imipramine itself; it warns about its class (Tricyclic antidepressants):
Sertraline label, drug interactionsIf serotonin syndrome occurs, consider discontinuation of ZOLOFT and/or concomitant serotonergic drugs [See Warnings and Precautions (5.2) ]. Other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines, and St. John’s Wort.
Sertraline label, warnings and precautionsThe risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. John’s Wort) and with drugs that impair metabolism of serotonin, i.e., MAOIs [See Contraindications (4), Drug Interactions (7.1) ].
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Imipramine | Sertraline | |
|---|---|---|
| Labeled for | Depression | Depression, Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0698 per tablet 10 mg tablet | $0.0507 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once