What the FDA labels say about taking them together
Epinephrine and imipramine
Epinephrine's FDA label of July 13, 2026 names imipramine in its warnings and precautions section, and imipramine's label names epinephrine too. The imipramine label: “Avoid the use of preparations, such as decongestants and local anesthetics, that contain any sympathomimetic amine, since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines.”
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the imipramine FDA label on DailyMed (effective August 11, 2026, Leading Pharma, LLC).
What does the epinephrine label say about imipramine?
Epinephrine label, warnings and precautionsPatients receiving monoamine oxidase inhibitors (MAOI) or antidepressants of triptyline or imipramine types may experience severe, prolonged hypertension when given epinephrine.
Source: FDA drug label (Adrenalin (Epinephrine In Sodium Chloride), NDA215875), Par Health USA, LLC, effective August 1, 2023 (SPL set 61b0e2a2-71ed-43d6-b1a7-36d2dae651b5), via openFDA
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the imipramine label say about epinephrine?
Imipramine label, drug interactionsAvoid the use of preparations, such as decongestants and local anesthetics, that contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines.
Source: FDA drug label (Imipramine Hydrochloride), Leading Pharma, LLC, effective August 11, 2026 (SPL set 490263ce-b4d2-428a-87da-fcd07f85499a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Imipramine | |
|---|---|---|
| Labeled for | Asthma | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | $0.0698 per tablet 10 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once