Imipramine and Norepinephrine Interaction
Drug interaction information between Imipramine and Norepinephrine.
Imipramine and Norepinephrine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Imipramine and Norepinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Imipramine can make the effects of norepinephrine much stronger, which could lead to serious side effects.
FDA Label Information
Avoid the use of preparations, such as decongestants and local anesthetics, that contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines.
Imipramine Also Interacts With
- Epinephrine moderate
- Zolpidem moderate
- Sertraline minor
- Paroxetine minor
- Flecainide minor
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Imipramine + Norepinephrine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Imipramine's 20. In the moderate band specifically: Imipramine has 3 (also Epinephrine, Zolpidem); Norepinephrine has 7 (also Carbidopa/Levodopa, Clopidogrel, Deutetrabenazine, Digoxin).
What mechanism field is on file for Imipramine and Norepinephrine?
Imipramine can make the effects of norepinephrine much stronger, which could lead to serious side effects.
Norepinephrine carries more major-labeled pairs than Imipramine
SPL source-record counts only. This page's band is moderate · classes on file: Imipramine (Tricyclic Antidepressant (TCA)); Norepinephrine (Vasopressor (Alpha-1 Agonist)).
Norepinephrine has 1 major-labeled pair vs Imipramine's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 17 minor · 20 total
- Other moderate peers for Imipramine
- Epinephrine
- Zolpidem
1 major · 7 moderate · 42 minor · 50 total
- Other moderate peers for Norepinephrine
- Carbidopa/Levodopa
- Clopidogrel
- Deutetrabenazine
- Digoxin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.