What the FDA labels say about taking them together
Imipramine and norepinephrine
Norepinephrine's FDA label of June 12, 2025 names imipramine in its drug interactions section; the imipramine label PlainMeds reads does not name norepinephrine. The norepinephrine label: “DRUG INTERACTIONS Monoamine oxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types may result in hypertension. Cyclopropane and halothane anesthetics increase cardiac autonomic irritability.”
Check it at the source: the imipramine FDA label on DailyMed (effective August 11, 2026, Leading Pharma, LLC); the norepinephrine FDA label on DailyMed (effective June 12, 2025, Hospira, Inc.).
What does the imipramine label say about norepinephrine?
Imipramine's label (effective August 11, 2026) does not name norepinephrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Imipramine Hydrochloride), Leading Pharma, LLC, effective August 11, 2026 (SPL set 490263ce-b4d2-428a-87da-fcd07f85499a), via openFDA; the full label on DailyMed
What does the norepinephrine label say about imipramine?
Norepinephrine label, drug interactionsMonoamine oxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types may result in hypertension.
Norepinephrine label (Long Grove Pharmaceuticals, LLC, December 4, 2025), drug interactionsDRUG INTERACTIONS Monoamine oxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types may result in hypertension. ( 7.1 ) Cyclopropane and halothane anesthetics increase cardiac autonomic irritability.
Source: FDA drug label (Norepinephrine Bitartrate, NDA214313), Baxter Healthcare Corporation, effective February 6, 2026 (SPL set 6363e9b4-29df-4553-904d-a563e5adda6e), via openFDA
Source: FDA drug label (Norepinephrine, NDA214628), Long Grove Pharmaceuticals, LLC, effective December 4, 2025 (SPL set 759807dd-61a8-4f6f-8bf5-f6ee773c81bc), via openFDA
Source: FDA drug label (LEVOPHED), Hospira, Inc., effective June 12, 2025 (SPL set 2c7dd2b0-cc10-4db6-bf56-6eb154ebeb10), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Imipramine | Norepinephrine | |
|---|---|---|
| Labeled for | Depression | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0698 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once