Imipramine and Zolpidem Interaction
Drug interaction information between Imipramine and Zolpidem.
Imipramine and Zolpidem have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Imipramine and Zolpidem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs slow down the central nervous system, which can lead to a combined effect that makes you feel much less alert.
FDA Label Information
7 DRUG INTERACTIONS CNS depressants, including alcohol: Possible adverse additive CNS- depressant effects ( 5.1 , 7.1 ) Opioids: Concomitant use may increase risk of respiratory depression ( 5.7 , 7.1 ) Imipramine: Decreased alertness observed ( 7.1 ) Chlorpromazine: Impaired alertness and psychomotor performance observed ( 7.1 ) CYP3A4 inducers (rifampin or St. Limit dosage and duration of concomitant use of Zolpidem Tartrate Tablets and opioids [ see Dosage and Administration ( 2.3 ), Warnings and Precautions ( 5.7 )] Imipramine, Chlorpromazine Imipramine in combination with Zolpidem...
Imipramine Also Interacts With
- Epinephrine moderate
- Norepinephrine moderate
- Sertraline minor
- Paroxetine minor
- Flecainide minor
Zolpidem Also Interacts With
- Ketoconazole moderate
- Rifampin moderate
- Chlorpromazine moderate
- Sertraline minor
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Imipramine + Zolpidem?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Imipramine has 20 labeled pairs on file vs Zolpidem's 9. In the moderate band specifically: Imipramine has 3 (also Epinephrine, Norepinephrine); Zolpidem has 4 (also Ketoconazole, Rifampin, Chlorpromazine).
What mechanism field is on file for Imipramine and Zolpidem?
Both drugs slow down the central nervous system, which can lead to a combined effect that makes you feel much less alert.
Imipramine's labeled portfolio outnumbers Zolpidem
SPL source-record counts only. This page's band is moderate · classes on file: Imipramine (Tricyclic Antidepressant (TCA)); Zolpidem (Non-Benzodiazepine Hypnotic (Z-Drug)).
0 major · 3 moderate · 17 minor · 20 total
- Other moderate peers for Imipramine
- Epinephrine
- Norepinephrine
0 major · 4 moderate · 5 minor · 9 total
- Other moderate peers for Zolpidem
- Ketoconazole
- Rifampin
- Chlorpromazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.