Anidulafungin and Amphotericin B Interaction
Drug interaction information between Anidulafungin and Amphotericin B.
Anidulafungin and Amphotericin B have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Anidulafungin and Amphotericin B. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications do not interfere with each other's levels in the body. They do not change how the body processes the medicine.
FDA Label Information
7.5 Amphotericin B Liposome for Injection Administration of multiple doses of anidulafungin and liposomal amphotericin B to patients resulted in no significant alteration in the steady state pharmacokinetics of anidulafungin. No dosage adjustment of anidulafungin is needed when it is co-administered with liposomal amphotericin B [see Clinical Pharmacology (12.3) ] .
Anidulafungin Also Interacts With
- Cyclosporine minor
- Rifampin minor
- Voriconazole minor
Amphotericin B Also Interacts With
- Cidofovir major
- Ganciclovir moderate
- Valganciclovir moderate
- Ketoconazole minor
- Dexamethasone minor
Frequently Asked Questions
What SPL severity band is on file for Anidulafungin + Amphotericin B?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amphotericin B has 12 labeled pairs on file vs Anidulafungin's 4. In the minor band specifically: Anidulafungin has 4 (also Cyclosporine, Rifampin, Voriconazole); Amphotericin B has 9 (also Ketoconazole, Dexamethasone, Dronabinol, Fluconazole).
What mechanism field is on file for Anidulafungin and Amphotericin B?
These medications do not interfere with each other's levels in the body. They do not change how the body processes the medicine.
Amphotericin B carries more major-labeled pairs than Anidulafungin
SPL source-record counts only. This page's band is minor · classes on file: Anidulafungin (Echinocandin Antifungal); Amphotericin B (Polyene Antifungal).
Amphotericin B has 1 major-labeled pair vs Anidulafungin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Anidulafungin
- Cyclosporine
- Rifampin
- Voriconazole
1 major · 2 moderate · 9 minor · 12 total
- Other minor peers for Amphotericin B
- Ketoconazole
- Dexamethasone
- Dronabinol
- Fluconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.