Anidulafungin and Rifampin Interaction
Drug interaction information between Anidulafungin and Rifampin.
Anidulafungin and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Anidulafungin and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medicines together does not change the level of either drug in your system. They do not interfere with how the body handles the medication.
FDA Label Information
7.4 Rifampin Administration of multiple doses of anidulafungin and rifampin to patients resulted in no significant alteration in the steady state pharmacokinetics of anidulafungin. No dosage adjustment of anidulafungin is needed when it is co-administered with rifampin [see Clinical Pharmacology (12.3) ] .
Anidulafungin Also Interacts With
- Cyclosporine minor
- Voriconazole minor
- Amphotericin B minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Anidulafungin + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Anidulafungin's 4. In the minor band specifically: Anidulafungin has 4 (also Cyclosporine, Voriconazole, Amphotericin B); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Anidulafungin and Rifampin?
Taking these medicines together does not change the level of either drug in your system. They do not interfere with how the body handles the medication.
Rifampin carries more major-labeled pairs than Anidulafungin
SPL source-record counts only. This page's band is minor · classes on file: Anidulafungin (Echinocandin Antifungal); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Anidulafungin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Anidulafungin
- Cyclosporine
- Voriconazole
- Amphotericin B
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.