Anidulafungin and Cyclosporine Interaction
Drug interaction information between Anidulafungin and Cyclosporine.
Anidulafungin and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Anidulafungin and Cyclosporine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two drugs do not change how the body processes or breaks down each other. They can be used together without affecting the amount of medicine in your blood.
What To Do
No dose changes are needed when taking these two medications at the same time.
FDA Label Information
7 DRUG INTERACTIONS 7.1 Cyclosporine Administration of multiple doses of anidulafungin and cyclosporine to healthy subjects resulted in no significant alteration in the steady state pharmacokinetics of either drug. No dosage adjustment of cyclosporine or anidulafungin is needed when the two drugs are co-administered [see Clinical Pharmacology (12.3) ] .
Anidulafungin Also Interacts With
- Rifampin minor
- Voriconazole minor
- Amphotericin B minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
Can I take Anidulafungin and Cyclosporine together?
This is a minor interaction. No dose changes are needed when taking these two medications at the same time.
How serious is the interaction between Anidulafungin and Cyclosporine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Anidulafungin and Cyclosporine interact?
These two drugs do not change how the body processes or breaks down each other. They can be used together without affecting the amount of medicine in your blood.
Understanding the Anidulafungin and Cyclosporine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Anidulafungin belongs to the Echinocandin Antifungal class and Cyclosporine belongs to the Calcineurin Inhibitor (Immunosuppressant) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two drugs do not change how the body processes or breaks down each other. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Anidulafungin has 4 total documented interactions on file in this dataset, and Cyclosporine has 89. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No dose changes are needed when taking these two medications at the same time. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Anidulafungin or Cyclosporine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.