Dronabinol and Ketoconazole Interaction
Drug interaction information between Dronabinol and Ketoconazole.
Dronabinol and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dronabinol and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole blocks the natural process your body uses to get rid of dronabinol. This can cause dronabinol levels to build up, making side effects more likely.
FDA Label Information
Monitor for potentially increased dronabinol-related adverse reactions when dronabinol capsules are co-administered with inhibitors of CYP2C9 (e.g., amiodarone, fluconazole) and inhibitors of CYP3A4 enzymes (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, erythromycin, grapefruit juice).
Dronabinol Also Interacts With
- Warfarin minor
- Fluconazole minor
- Cyclosporine minor
- Erythromycin minor
- Clarithromycin minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Dronabinol + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Dronabinol's 9. In the minor band specifically: Dronabinol has 9 (also Warfarin, Fluconazole, Cyclosporine, Erythromycin); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Dronabinol and Ketoconazole?
Ketoconazole blocks the natural process your body uses to get rid of dronabinol. This can cause dronabinol levels to build up, making side effects more likely.
Ketoconazole carries more major-labeled pairs than Dronabinol
SPL source-record counts only. This page's band is minor · classes on file: Dronabinol (Cannabinoid Antiemetic); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Dronabinol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Dronabinol
- Warfarin
- Fluconazole
- Cyclosporine
- Erythromycin
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.