Dronabinol and Warfarin Interaction
Drug interaction information between Dronabinol and Warfarin.
Dronabinol and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dronabinol and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dronabinol can push warfarin off the proteins in your blood that normally hold it. This leaves more active warfarin in your system, which can increase the risk of bleeding.
FDA Label Information
(7.3) Highly protein-bound drugs: Potential for displacement of other drugs from plasma proteins; monitor for adverse reactions to concomitant highly protein-bound drugs and narrow therapeutic index drugs (e.g., warfarin, cyclosporine, amphotericin B) when initiating or increasing the dosage of dronabinol capsules. Although this displacement has not been confirmed in vivo , monitor patients for increased adverse reactions to narrow therapeutic index drugs that are highly protein-bound (e.g., warfarin, cyclosporine, amphotericin B) when initiating treatment or increasing the dosage of...
Dronabinol Also Interacts With
- Ketoconazole minor
- Fluconazole minor
- Cyclosporine minor
- Erythromycin minor
- Clarithromycin minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Dronabinol + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Dronabinol's 9. In the minor band specifically: Dronabinol has 9 (also Ketoconazole, Fluconazole, Cyclosporine, Erythromycin); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Dronabinol and Warfarin?
Dronabinol can push warfarin off the proteins in your blood that normally hold it. This leaves more active warfarin in your system, which can increase the risk of bleeding.
Warfarin carries more major-labeled pairs than Dronabinol
SPL source-record counts only. This page's band is minor · classes on file: Dronabinol (Cannabinoid Antiemetic); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Dronabinol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Dronabinol
- Ketoconazole
- Fluconazole
- Cyclosporine
- Erythromycin
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.