Dronabinol and Cyclosporine Interaction
Drug interaction information between Dronabinol and Cyclosporine.
Dronabinol and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dronabinol and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dronabinol may knock cyclosporine off the proteins it usually sticks to in your blood, making the cyclosporine more active.
FDA Label Information
(7.3) Highly protein-bound drugs: Potential for displacement of other drugs from plasma proteins; monitor for adverse reactions to concomitant highly protein-bound drugs and narrow therapeutic index drugs (e.g., warfarin, cyclosporine, amphotericin B) when initiating or increasing the dosage of dronabinol capsules. Although this displacement has not been confirmed in vivo , monitor patients for increased adverse reactions to narrow therapeutic index drugs that are highly protein-bound (e.g., warfarin, cyclosporine, amphotericin B) when initiating treatment or increasing the dosage of...
Dronabinol Also Interacts With
- Warfarin minor
- Ketoconazole minor
- Fluconazole minor
- Erythromycin minor
- Clarithromycin minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Dronabinol + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Dronabinol's 9. In the minor band specifically: Dronabinol has 9 (also Warfarin, Ketoconazole, Fluconazole, Erythromycin); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Dronabinol and Cyclosporine?
Dronabinol may knock cyclosporine off the proteins it usually sticks to in your blood, making the cyclosporine more active.
Cyclosporine carries more major-labeled pairs than Dronabinol
SPL source-record counts only. This page's band is minor · classes on file: Dronabinol (Cannabinoid Antiemetic); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Dronabinol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Dronabinol
- Warfarin
- Ketoconazole
- Fluconazole
- Erythromycin
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.