What the FDA labels say about taking them together
Dronabinol and fluconazole
Dronabinol's FDA label of May 6, 2026 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name dronabinol. The dronabinol label: “Monitor for increased dronabinol-related adverse reactions when SYNDROS is co-administered with inhibitors of CYP2C9 and inhibitors of CYP3A4 enzymes.”
Check it at the source: the dronabinol FDA label on DailyMed (effective May 6, 2026, Ascend Laboratories, LLC); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the dronabinol label say about fluconazole?
Dronabinol label, drug interactionsMonitor for potentially increased dronabinol-related adverse reactions when dronabinol capsules are co-administered with inhibitors of CYP2C9 (e.g., amiodarone, fluconazole) and inhibitors of CYP3A4 enzymes (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, erythromycin, grapefruit juice).
Source: FDA drug label (Syndros, NDA205525), Wellhouse Pharma, LLC, effective April 17, 2026 (SPL set 3cdcb4f5-5af9-4ff7-b535-2a5cf4c6da89), via openFDA
Source: FDA drug label (Dronabinol), NDA018651 (Alkem Labs Ltd), as published by Ascend Laboratories, LLC, effective May 6, 2026 (SPL set adb1801c-0fb5-4e16-b969-1db91230e0b9), via openFDA; the full label on DailyMed
What does the fluconazole label say about dronabinol?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name dronabinol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dronabinol | Fluconazole | |
|---|---|---|
| Labeled for | n/a | Fungal infections, Urinary tract infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $3.35 per capsule 5 mg capsule | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once