Dronabinol and Fluconazole Interaction
Drug interaction information between Dronabinol and Fluconazole.
Dronabinol and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dronabinol and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole stops the liver from breaking down dronabinol, which can lead to higher levels of the drug in your blood.
FDA Label Information
Monitor for potentially increased dronabinol-related adverse reactions when dronabinol capsules are co-administered with inhibitors of CYP2C9 (e.g., amiodarone, fluconazole) and inhibitors of CYP3A4 enzymes (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, erythromycin, grapefruit juice).
Dronabinol Also Interacts With
- Warfarin minor
- Ketoconazole minor
- Cyclosporine minor
- Erythromycin minor
- Clarithromycin minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Dronabinol + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Dronabinol's 9. In the minor band specifically: Dronabinol has 9 (also Warfarin, Ketoconazole, Cyclosporine, Erythromycin); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Dronabinol and Fluconazole?
Fluconazole stops the liver from breaking down dronabinol, which can lead to higher levels of the drug in your blood.
Fluconazole carries more major-labeled pairs than Dronabinol
SPL source-record counts only. This page's band is minor · classes on file: Dronabinol (Cannabinoid Antiemetic); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Dronabinol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Dronabinol
- Warfarin
- Ketoconazole
- Cyclosporine
- Erythromycin
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.