Dronabinol and Erythromycin Interaction
Drug interaction information between Dronabinol and Erythromycin.
Dronabinol and Erythromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dronabinol and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin slows down the liver enzymes that process dronabinol, which can cause the drug to stay in your body longer.
FDA Label Information
Monitor for potentially increased dronabinol-related adverse reactions when dronabinol capsules are co-administered with inhibitors of CYP2C9 (e.g., amiodarone, fluconazole) and inhibitors of CYP3A4 enzymes (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, erythromycin, grapefruit juice).
Dronabinol Also Interacts With
- Warfarin minor
- Ketoconazole minor
- Fluconazole minor
- Cyclosporine minor
- Clarithromycin minor
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Dronabinol + Erythromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Dronabinol's 9. In the minor band specifically: Dronabinol has 9 (also Warfarin, Ketoconazole, Fluconazole, Cyclosporine); Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Atorvastatin, Bromocriptine).
What mechanism field is on file for Dronabinol and Erythromycin?
Erythromycin slows down the liver enzymes that process dronabinol, which can cause the drug to stay in your body longer.
Erythromycin carries more major-labeled pairs than Dronabinol
SPL source-record counts only. This page's band is minor · classes on file: Dronabinol (Cannabinoid Antiemetic); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Dronabinol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Dronabinol
- Warfarin
- Ketoconazole
- Fluconazole
- Cyclosporine
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Atorvastatin
- Bromocriptine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.