What the FDA labels say about taking them together
Fluconazole and fluvastatin
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names fluvastatin in its drug interactions section, and fluvastatin's label names fluconazole too. The fluconazole label: “… CYP3A4, such as atorvastatin and simvastatin, or through CYP2C9, such as fluvastatin.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the fluvastatin FDA label on DailyMed (effective April 21, 2025, Teva Pharmaceuticals USA, Inc.).
What does the fluconazole label say about fluvastatin?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsHMG-CoA reductase inhibitors The risk of myopathy and rhabdomyolysis increases when fluconazole is coadministered with HMG-CoA reductase inhibitors metabolized through CYP3A4, such as atorvastatin and simvastatin, or through CYP2C9, such as fluvastatin (decreased hepatic metabolism of the statin).
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the fluvastatin label say about fluconazole?
Fluvastatin label, drug interactionsLimit fluvastatin dose to 20 mg ( 2.4 , 7.1 ) Fluconazole: Combination increases fluvastatin exposure.
Fluvastatin Sodium Er label (Sandoz Inc, January 31, 2024), drug interactionsCyclosporine and Fluconazole: Avoid use with fluvastatin sodium extended-release tablets.
Fluvastatin Sodium Er label (Sandoz Inc, January 31, 2024), warnings and precautionsSteps to Prevent or Reduce the Risk of Myopathy and Rhabdomyolysis Avoid concomitant use of fluvastatin sodium extended-release tablets with gemfibrozil, cyclosporin, and fluconazole.
Source: FDA drug label (Fluvastatin Sodium Er, NDA021192), Sandoz Inc, effective January 31, 2024 (SPL set 5ab4296c-87c2-4c64-b218-d620eef51310), via openFDA
Source: FDA drug label (Fluvastatin), Teva Pharmaceuticals USA, Inc., effective April 21, 2025 (SPL set aad8b373-0aec-4efb-8e61-3d8114b31127), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Fluvastatin | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | High cholesterol |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $2.88 per tablet 80 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once