Fluconazole and Fluvastatin Interaction
Drug interaction information between Fluconazole and Fluvastatin.
Fluconazole and Fluvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluconazole and Fluvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole prevents your body from properly breaking down fluvastatin, which can cause the drug to reach levels that damage your muscles.
FDA Label Information
HMG-CoA reductase inhibitors : The risk of myopathy and rhabdomyolysis increases when fluconazole is coadministered with HMG-CoA reductase inhibitors metabolized through CYP3A4, such as atorvastatin and simvastatin, or through CYP2C9, such as fluvastatin.
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Fluvastatin Also Interacts With
- Clarithromycin major
- Cyclosporine moderate
- Glyburide moderate
- Gemfibrozil moderate
- Niacin moderate
Frequently Asked Questions
What SPL severity band is on file for Fluconazole + Fluvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Fluvastatin's 12. In the moderate band specifically: Fluconazole has 7 (also Atorvastatin, Simvastatin, Carbamazepine, Amiodarone); Fluvastatin has 6 (also Cyclosporine, Glyburide, Gemfibrozil, Niacin).
What mechanism field is on file for Fluconazole and Fluvastatin?
Fluconazole prevents your body from properly breaking down fluvastatin, which can cause the drug to reach levels that damage your muscles.
Fluconazole carries more major-labeled pairs than Fluvastatin
SPL source-record counts only. This page's band is moderate · classes on file: Fluconazole (Azole Antifungal); Fluvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Fluconazole has 3 major-labeled pairs vs Fluvastatin's 1. This page itself is in the moderate band, not the major band.
3 major · 7 moderate · 57 minor · 67 total
- Other moderate peers for Fluconazole
- Atorvastatin
- Simvastatin
- Carbamazepine
- Amiodarone
1 major · 6 moderate · 5 minor · 12 total
- Other moderate peers for Fluvastatin
- Cyclosporine
- Glyburide
- Gemfibrozil
- Niacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.