Tramadol and Gabapentin Interaction
Drug interaction information between Tramadol and Gabapentin.
Tramadol and Gabapentin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tramadol and Gabapentin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can slow down brain activity and breathing. Taking them together increases the risk of feeling very sleepy or having trouble breathing.
FDA Label Information
Examples: Benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin) , other opioids, alcohol.
Tramadol Also Interacts With
- Safinamide major
- Carbamazepine moderate
- Rifampin moderate
- Phenytoin moderate
- Bupropion minor
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Oxycodone minor
- Estradiol minor
- Naproxen minor
- Norethindrone minor
Frequently Asked Questions
What SPL severity band is on file for Tramadol + Gabapentin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tramadol has 38 labeled pairs on file vs Gabapentin's 19. In the minor band specifically: Tramadol has 34 (also Bupropion, Fluoxetine, Cyclobenzaprine, Paroxetine); Gabapentin has 18 (also Oxycodone, Estradiol, Naproxen, Norethindrone).
What mechanism field is on file for Tramadol and Gabapentin?
Both of these medicines can slow down brain activity and breathing. Taking them together increases the risk of feeling very sleepy or having trouble breathing.
Tramadol carries more major-labeled pairs than Gabapentin
SPL source-record counts only. This page's band is minor · classes on file: Tramadol (Opioid Analgesic); Gabapentin (Anticonvulsant / Nerve Pain Agent).
Tramadol has 1 major-labeled pair vs Gabapentin's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 34 minor · 38 total
- Other minor peers for Tramadol
- Bupropion
- Fluoxetine
- Cyclobenzaprine
- Paroxetine
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Gabapentin
- Oxycodone
- Estradiol
- Naproxen
- Norethindrone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.