Tramadol and Rifampin Interaction
Drug interaction information between Tramadol and Rifampin.
Tramadol and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tramadol and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the process of clearing the pain medicine from your body. This can lead to the pain medicine not working as well as it should.
FDA Label Information
Examples: Rifampin, carbamazepine, phenytoin Benzodiazepines and Other Central Nervous System (CNS) Depressants Clinical Impact: Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death [see Warnings and Precautions (5.3) ].
Tramadol Also Interacts With
- Safinamide major
- Carbamazepine moderate
- Phenytoin moderate
- Gabapentin minor
- Bupropion minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Tramadol + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Tramadol's 38. In the moderate band specifically: Tramadol has 3 (also Carbamazepine, Phenytoin); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Tramadol and Rifampin?
Rifampin speeds up the process of clearing the pain medicine from your body. This can lead to the pain medicine not working as well as it should.
Rifampin carries more major-labeled pairs than Tramadol
SPL source-record counts only. This page's band is moderate · classes on file: Tramadol (Opioid Analgesic); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Tramadol's 1. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 34 minor · 38 total
- Other moderate peers for Tramadol
- Carbamazepine
- Phenytoin
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.