Tramadol and Cyclobenzaprine Interaction
Drug interaction information between Tramadol and Cyclobenzaprine.
Tramadol and Cyclobenzaprine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tramadol and Cyclobenzaprine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase a brain chemical called serotonin. Taking them at the same time can cause serotonin levels to get too high.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Tramadol Also Interacts With
- Safinamide major
- Carbamazepine moderate
- Rifampin moderate
- Phenytoin moderate
- Gabapentin minor
Cyclobenzaprine Also Interacts With
- Clozapine moderate
- Tapentadol moderate
- Tranylcypromine moderate
- Acetaminophen/Oxycodone minor
- Buprenorphine minor
Frequently Asked Questions
What SPL severity band is on file for Tramadol + Cyclobenzaprine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tramadol has 38 labeled pairs on file vs Cyclobenzaprine's 17. In the minor band specifically: Tramadol has 34 (also Gabapentin, Bupropion, Fluoxetine, Paroxetine); Cyclobenzaprine has 14 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine).
What mechanism field is on file for Tramadol and Cyclobenzaprine?
Both drugs increase a brain chemical called serotonin. Taking them at the same time can cause serotonin levels to get too high.
Tramadol carries more major-labeled pairs than Cyclobenzaprine
SPL source-record counts only. This page's band is minor · classes on file: Tramadol (Opioid Analgesic); Cyclobenzaprine (Muscle Relaxant).
Tramadol has 1 major-labeled pair vs Cyclobenzaprine's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 34 minor · 38 total
- Other minor peers for Tramadol
- Gabapentin
- Bupropion
- Fluoxetine
- Paroxetine
0 major · 3 moderate · 14 minor · 17 total
- Other minor peers for Cyclobenzaprine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.