Tramadol and Bupropion Interaction
Drug interaction information between Tramadol and Bupropion.
Tramadol and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tramadol and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Bupropion stops the body from breaking down tramadol normally. This can lead to higher levels of the drug and its active parts in your system, which may increase side effects.
FDA Label Information
Examples Quinidine, fluoxetine, paroxetine and bupropion Inhibitors of CYP3A4 Clinical Impact: The concomitant use of tramadol hydrochloride extended-release tablets and CYP3A4 inhibitors can increase the plasma concentration of tramadol and may result in a greater amount of metabolism via CYP2D6 and greater levels of M1.
Tramadol Also Interacts With
- Safinamide major
- Carbamazepine moderate
- Rifampin moderate
- Phenytoin moderate
- Gabapentin minor
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Tramadol + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tramadol has 38 labeled pairs on file vs Bupropion's 35. In the minor band specifically: Tramadol has 34 (also Gabapentin, Fluoxetine, Cyclobenzaprine, Paroxetine); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Tramadol and Bupropion?
Bupropion stops the body from breaking down tramadol normally. This can lead to higher levels of the drug and its active parts in your system, which may increase side effects.
Tramadol's labeled portfolio outnumbers Bupropion
SPL source-record counts only. This page's band is minor · classes on file: Tramadol (Opioid Analgesic); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
1 major · 3 moderate · 34 minor · 38 total
- Other minor peers for Tramadol
- Gabapentin
- Fluoxetine
- Cyclobenzaprine
- Paroxetine
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.