Prescription medication · Tetracycline Antibiotic (Antimalarial)

doxycycline hyclate

Name: doxycycline hyclate - FDA Drug Safety & Adverse Event Data
Creator: PlainMeds
License: https://creativecommons.org/publicdomain/zero/1.0/

Also sold as Doryx MPC. This medicine can treat infections like Rocky Mountain spotted fever and typhus.

Compiled by PlainMeds, Drug Information Editorial Process

Data updated 2026-05-15

63,762
FDA reportsOften reported: 5
InteractionsFew interactions: $0.11
Generic price (NADAC)

What the data shows

doxycycline hyclate (Doryx MPC) is a prescription Tetracycline Antibiotic (Antimalarial), more reported than most tracked drugs (63,762 FDA reports), with 5 documented drug interactions.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

doxycycline hyclate (Doryx MPC) is a prescription Tetracycline Antibiotic (Antimalarial). This medicine can treat infections like Rocky Mountain spotted fever and typhus.

Doxycycline hyclate is an antibiotic that fights bacteria in your body. It can treat many different types of infections.

Verify with FDA → · CMS NADAC pricing →

Drug Pricing (NADAC)

Generic Price

$0.11/unit

Generic Available

Yes (32 manufacturers)

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

NADAC price trail: DOXYCYCLINE HYCLATE 100 MG CAP

Same CMS presentation as the headline generic unit price above (2 effective dates). Adjacent % compares consecutive NADAC releases for this description only, not a patient out-of-pocket quote. Latest step: -24.5% vs prior release.

Effective	NADAC / unit	vs prior	NDCs
February 21, 2024	$0.1414/EA	-	2
December 18, 2024	$0.1067/EA	-24.5%	21

Compare with Another Drug → Full Side Effects Report →

What it does

This medicine can treat infections like Rocky Mountain spotted fever and typhus.

Common side effects

Nausea, Vomiting, Diarrhea

Key warnings

Doxycycline can cause permanent tooth discoloration if used during tooth development.

The sections below are summarized in plain English from doxycycline hyclate's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Doxycycline stops bacteria from growing by interfering with how they make proteins. This helps your body fight off the infection. It is a tetracycline antibiotic.

Side Effects (from patient reports)

Based on 63,762 FDA adverse event reports.

Nausea

4,733
Fatigue

4,376
Rash

3,919
Diarrhoea

3,813
Pain

3,796
Dyspnoea

3,786
Headache

3,723
Vomiting

3,658
Drug Hypersensitivity

3,630
Malaise

2,812

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Reports over time

Adverse-event reports filed for doxycycline hyclate each year to the FDA Adverse Event Reporting System (FAERS).

Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.

Where doxycycline hyclate sits

doxycycline hyclate has more FDA adverse-event reports than 78% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.

fewest reports most reports

Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is doxycycline hyclate; the line is the median (50th percentile).

FDA Adverse Event Report Analysis

Detailed analysis of 63,762 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2003–2025.

Total Reports

63,762

Reports Mentioning Death

6,312

9.9% of reports — not proof of cause

Hospitalization Reports

20,575

Top Indication

Product Used For Unknown Indication

Gender Distribution

Female 36,519 (63%)

Male 21,321 (37%)

Age Distribution

0–17 1,693

18–44 13,107

45–64 14,257

65–74 8,419

75+ 6,843

Most Reported Adverse Reactions (FAERS)

#	Reaction	Reports
2	NAUSEA	4,733
4	FATIGUE	4,376
5	RASH	3,919
6	DIARRHOEA	3,813
7	PAIN	3,796
8	DYSPNOEA	3,786
9	HEADACHE	3,723
10	VOMITING	3,658
11	DRUG HYPERSENSITIVITY	3,630
12	MALAISE	2,812
13	CONDITION AGGRAVATED	2,770
14	DIZZINESS	2,755
15	PRURITUS	2,729
16	ARTHRALGIA	2,650
17	CHRONIC KIDNEY DISEASE	2,618

Reactions in Death Reports

DEATH 1,422

FATIGUE 1,050

HYPERTENSION 961

HYPOAESTHESIA 956

GENERAL PHYSICAL HEALTH DETERIORATION 946

VOMITING 941

HYPERSENSITIVITY 921

RASH 921

GLOSSODYNIA 916

PYREXIA 915

Reactions in Hospitalization Reports

DYSPNOEA 2,216

FATIGUE 2,066

NAUSEA 1,901

VOMITING 1,864

PAIN 1,842

PNEUMONIA 1,829

DIARRHOEA 1,826

PYREXIA 1,740

RASH 1,687

HEADACHE 1,557

Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation

Serious Warnings

Doxycycline can cause permanent tooth discoloration if used during tooth development. Tell your doctor if you have kidney problems.

Known Drug Interactions

moderate tetracycline

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin. Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.

Mechanism: These drugs are very similar and work in the same way, so taking them together can lead to too much medicine in your system and more side effects.

minor doxycycline

Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.

Mechanism: Certain medications can cause your body to clear doxycycline from your system much faster than usual.

minor carbamazepine

Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.

Mechanism: Carbamazepine causes your body to break down doxycycline faster than it should. This means the antibiotic leaves your system too quickly to work effectively.

minor bismuth subsalicylate

Absorption of tetracyclines is impaired by bismuth subsalicylate.

Mechanism: Bismuth subsalicylate stops your body from absorbing doxycycline into your blood. This can prevent the antibiotic from working to kill bacteria.

minor phenytoin

Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.

Mechanism: Phenytoin speeds up how fast your body gets rid of doxycycline. This lowers the amount of medicine in your body, which might make it less effective.

This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

Can I take doxycycline with food?

Yes, you can take doxycycline with food or milk if it upsets your stomach.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it's close to your next dose, skip the missed dose.

Can doxycycline affect my birth control?

Yes, doxycycline may make oral contraceptives less effective. Talk to your doctor about other birth control options.

How long should I take doxycycline?

Take doxycycline for as long as your doctor tells you, even if you feel better.

Can doxycycline cause sun sensitivity?

Yes, doxycycline can make your skin more sensitive to the sun. Wear sunscreen and protective clothing when you are outside.

Can I drink alcohol while taking doxycycline?

It's best to avoid alcohol while taking doxycycline, as it can decrease the drug's effectiveness.

What if I experience severe diarrhea?

Tell your doctor right away if you have severe diarrhea while taking doxycycline.

Can doxycycline cause yeast infections?

Yes, doxycycline can sometimes cause yeast infections. Talk to your doctor if you think you have a yeast infection.

Is it safe to take doxycycline if I have kidney problems?

Talk to your doctor if you have kidney problems, as doxycycline can affect kidney function.

Can doxycycline cause tooth discoloration?

Yes, doxycycline can cause permanent tooth discoloration if used during tooth development (in children).

What are the common side effects of doxycycline hyclate?

The registry lists Nausea, Vomiting, Diarrhea among the most-reported FAERS reaction terms for doxycycline hyclate. The compiled record contains 63,762 FDA adverse-event reports. These counts are not an individual symptom assessment.

Does doxycycline hyclate interact with other medications?

The registry has 5 documented interaction rows for doxycycline hyclate. Notable source-record pairings include tetracycline, doxycycline, carbamazepine. These rows are not a complete medication review.

What drug class is doxycycline hyclate?

doxycycline hyclate belongs to the Tetracycline Antibiotic (Antimalarial) drug class. It requires a prescription (Rx). This medicine can treat infections like Rocky Mountain spotted fever and typhus.

What pregnancy or breastfeeding source fields are listed for doxycycline hyclate?

The FDA label for doxycycline hyclate contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

Other drugs grouped near doxycycline hyclate - same-class peers and common alternatives.

acyclovir

Zovirax

Acyclovir is an antiviral medicine.