Prescription medication · Aldosterone Antagonist
eplerenone
Also sold as Inspra. Eplerenone is used to help people with heart failure who have had a heart attack live longer.
Data updated 2026-05-15
- 12,113
- FDA reportsModerately reported
- 12
- InteractionsSeveral interactions
- 97% less
- Generic vs brandHuge savings
- $14.17
- Brand price (NADAC)
What the data shows
eplerenone (Inspra) is a prescription Aldosterone Antagonist, reported less often than most tracked drugs (12,113 FDA reports), whose generic costs a fraction of the brand (about 97% less).
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
eplerenone (Inspra) is a prescription Aldosterone Antagonist. Eplerenone is used to help people with heart failure who have had a heart attack live longer.
Eplerenone (Inspra) helps you live longer if you have heart failure after a heart attack. It also lowers blood pressure if you have high blood pressure.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Brand Price
$14.17/unit
Generic Price
$0.37/unit
Generic Savings
97%
Generic Available
Yes (5 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
NADAC price trail: EPLERENONE 25 MG TABLET
Same CMS presentation as the headline generic unit price above (4 effective dates). Adjacent % compares consecutive NADAC releases for this description only, not a patient out-of-pocket quote. Latest step: -7% vs prior release.
| Effective | NADAC / unit | vs prior | NDCs |
|---|---|---|---|
| February 21, 2024 | $0.6396/EA | - | 1 |
| July 17, 2024 | $0.4211/EA | -34.2% | 1 |
| October 23, 2024 | $0.3975/EA | -5.6% | 1 |
| December 18, 2024 | $0.3696/EA | -7% | 14 |
What it does
Eplerenone is used to help people with heart failure who have had a heart attack live longer.
Common side effects
High potassium levels in your blood, Increased creatinine levels
Key warnings
Eplerenone can cause high potassium levels in your blood, which can be dangerous.
The sections below are summarized in plain English from eplerenone's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Eplerenone blocks a hormone called aldosterone in your body. Aldosterone can cause your body to hold onto too much salt and water, which can raise blood pressure and worsen heart failure. By blocking aldosterone, eplerenone helps lower blood pressure and reduce strain on the heart.
Side Effects (from patient reports)
Based on 12,113 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for eplerenone, by number of reports
- Dyspnoea
Dyspnoea
1,083 reports
- Cardiac Failure
Cardiac Failure
939 reports
- Acute Kidney Injury
Acute Kidney Injury
905 reports
- Hypotension
Hypotension
859 reports
- Fatigue
Fatigue
659 reports
- Dizziness
Dizziness
650 reports
- Diarrhoea
Diarrhoea
551 reports
- Drug Interaction
Drug Interaction
529 reports
- Oedema Peripheral
Oedema Peripheral
521 reports
- Nausea
Nausea
487 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for eplerenone each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where eplerenone sits
eplerenone has more FDA adverse-event reports than 43% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is eplerenone; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 12,113 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
12,113
Reports Mentioning Death
1,200
9.9% of reports — not proof of cause
Hospitalization Reports
6,337
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DYSPNOEA | 1,083 |
| 2 | CARDIAC FAILURE | 939 |
| 3 | ACUTE KIDNEY INJURY | 905 |
| 4 | HYPOTENSION | 859 |
| 5 | FATIGUE | 659 |
| 6 | DIZZINESS | 650 |
| 7 | DIARRHOEA | 551 |
| 8 | DRUG INTERACTION | 529 |
| 9 | OEDEMA PERIPHERAL | 521 |
| 10 | NAUSEA | 487 |
| 13 | ASTHENIA | 437 |
| 14 | ATRIAL FIBRILLATION | 421 |
| 15 | FALL | 397 |
| 16 | HYPERKALAEMIA | 385 |
| 17 | CONDITION AGGRAVATED | 347 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Eplerenone can cause high potassium levels in your blood, which can be dangerous. Your doctor will check your potassium levels before you start taking eplerenone and regularly while you are taking it. People with kidney problems, diabetes, or who take certain other medicines are at higher risk.
Known Drug Interactions
7 DRUG INTERACTIONS • CYP3A Inhibitors: In post-MI HFrEF patients, do not exceed 25 mg once daily when used with moderate CYP3A inhibitors (e.g., verapamil, erythromycin, saquinavir, fluconazole).
Mechanism: Fluconazole blocks the enzyme that clears eplerenone from your body, which can lead to higher levels of the drug in your blood.
7 DRUG INTERACTIONS • CYP3A Inhibitors: In post-MI HFrEF patients, do not exceed 25 mg once daily when used with moderate CYP3A inhibitors (e.g., verapamil, erythromycin, saquinavir, fluconazole).
Mechanism: Verapamil slows down the body's ability to process eplerenone, which can cause the drug to reach higher levels in your blood.
7 DRUG INTERACTIONS • CYP3A Inhibitors: In post-MI HFrEF patients, do not exceed 25 mg once daily when used with moderate CYP3A inhibitors (e.g., verapamil, erythromycin, saquinavir, fluconazole).
Mechanism: Erythromycin blocks the proteins that break down eplerenone, leading to more of the drug staying in your body.
Diuretics Eplerenone Finerenone Contraindicated during and 2 weeks after itraconazole treatment.
Mechanism: Itraconazole prevents your body from processing eplerenone, which can cause the diuretic to reach toxic levels in your blood.
Cardiovascular agents eplerenone ↑ eplerenone Co-administration with eplerenone is contraindicated due to potential for hyperkalemia [see Contraindications (4) ] .
Mechanism: Nirmatrelvir/ritonavir raises the levels of eplerenone in your blood by slowing its breakdown. This can cause your potassium levels to become dangerously high.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I take eplerenone if I have kidney problems?
Can I take eplerenone if I have diabetes?
What should I do if I experience side effects?
Can I take eplerenone with other medications?
How long does it take for eplerenone to work?
Will eplerenone cure my condition?
Can I stop taking eplerenone if I feel better?
Does eplerenone have any effect on fertility?
What if my potassium level is too high?
Are there foods I should avoid while taking eplerenone?
What are the common side effects of eplerenone?
Does eplerenone interact with other medications?
What drug class is eplerenone?
Is there a generic version of eplerenone?
What pregnancy or breastfeeding source fields are listed for eplerenone?
Related Medications in Aldosterone Antagonist
Other drugs grouped near eplerenone - same-class peers and common alternatives.
acebutolol
Sectral
Acebutolol is a medicine that helps lower blood pressure and control irregular heartbeats.
Compare with eplerenone →
aliskiren
Tekturna
Tekturna is a medicine used to treat high blood pressure.
Compare with eplerenone →
amiloride
Midamor
Amiloride is a water pill that helps your body hold onto potassium.
Compare with eplerenone →
amlodipine
Norvasc
Amlodipine (Norvasc) is a drug that lowers blood pressure and treats chest pain.
Compare with eplerenone →
amlodipine/benazepril
Lotrel
Lotrel is a combination medicine that contains amlodipine and benazepril.
Compare with eplerenone →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for eplerenone: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 12,113.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 9.91%.
- doxycycline hyclate Δ 0.01 pts · 63,762 reports · Tetracycline Antibiotic (Antimalarial) 9.90%death share
- naproxen Δ 0.01 pts · 75,912 reports · Nonsteroidal Anti-Inflammatory Drug (NSAID) 9.92%death share
- famciclovir Δ 0.01 pts · 2,678 reports · Antiviral (Nucleoside Analog) 9.90%death share
- benralizumab Δ 0.01 pts · 17,680 reports · Anti-IL-5R Monoclonal Antibody 9.89%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
Save on eplerenone
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What the FDA Data Shows for eplerenone
The FDA label for eplerenone (sold under brand names such as Inspra) classifies it as a prescription-only medication in the Aldosterone Antagonist class. Eplerenone is used to help people with heart failure who have had a heart attack live longer. Official labeling lists 2 commonly reported side effects, including High potassium levels in your blood, Increased creatinine levels.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 12,113 voluntary reports. The database also lists 12 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $0.37 versus $14.17 for the brand - a 97% generic savings.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: June 23, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages