What the label lists and what reports show
Trimethobenzamide side effects
Trimethobenzamide's FDA label lists its adverse reactions in its own words. FAERS holds 1,415 reports naming it through July 30, 2026; the reaction reported most often, leaving out the conditions it is used for, product-use terms and outcomes, is somnolence (228 reports).
- Generic listed
Check it at the source: the trimethobenzamide FDA label on DailyMed (effective March 10, 2026, Par Health USA, LLC); the FDA FAERS public dashboard.
What does the label list?
From the label: adverse reactionsThere have been reports of hypersensitivity reactions and Parkinson-like symptoms. There have been instances of hypotension reported following parenteral administration to surgical patients. There have been reports of blood dyscrasias, blurring of vision, coma, convulsions, depression of mood, diarrhea, disorientation, dizziness, drowsiness, headache, jaundice, muscle cramps and opisthotonos. If these occur, the administration of the drug should be discontinued. Allergic-type skin reactions have been observed; therefore, the drug should be discontinued at the first sign of sensitization. While these symptoms will usually disappear spontaneously, symptomatic treatment may be indicated in some cases. For medical advice about adverse reactions contact your medical professional. …
Source: FDA drug label, Par Health USA, LLC, effective March 10, 2026 (SPL set 7da90678-b229-4ad6-9193-2b8a3e9ba695), via openFDA; the full label on DailyMed
What do FAERS reports show?
1,415 reports list trimethobenzamide among the medicines taken, each a report of something that happened, not proof the medicine caused it; 61 are coded as a death and 273 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is. Of the 22 reactions below, 1 is named by the same term (in US spelling) in the label's adverse reactions, warnings or patient leaflet; a reaction the label does not name may still be there under another word, and a report does not show that the medicine caused it.
Reports received each year
The 25 most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; reactions as MedDRA preferred terms
What next?
- Trimethobenzamide: the full record
- label, generics, price, shortages, recalls
- Report a side effect to the FDA
- MedWatch
- Side effects hub
- the most reported medicines and reactions