Vorapaxar and Itraconazole Interaction
Drug interaction information between Vorapaxar and Itraconazole.
Vorapaxar and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vorapaxar and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole stops your body from breaking down vorapaxar, which can cause the drug to build up to high levels. This happens because itraconazole blocks the enzymes that normally clear the medicine from your system.
FDA Label Information
Apixaban Rivaroxaban Vorapaxar Not recommended during and 2 weeks after itraconazole treatment.
Vorapaxar Also Interacts With
- Ketoconazole moderate
- Carbamazepine moderate
- Clarithromycin moderate
- Rifampin moderate
- Posaconazole moderate
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Vorapaxar + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Vorapaxar's 8. In the moderate band specifically: Vorapaxar has 7 (also Ketoconazole, Carbamazepine, Clarithromycin, Rifampin); Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Vorapaxar and Itraconazole?
Itraconazole stops your body from breaking down vorapaxar, which can cause the drug to build up to high levels. This happens because itraconazole blocks the enzymes that normally clear the medicine from your system.
Itraconazole carries more major-labeled pairs than Vorapaxar
SPL source-record counts only. This page's band is moderate · classes on file: Vorapaxar (PAR-1 Antagonist (Antiplatelet)); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Vorapaxar's 0. This page itself is in the moderate band, not the major band.
0 major · 7 moderate · 1 minor · 8 total
- Other moderate peers for Vorapaxar
- Ketoconazole
- Carbamazepine
- Clarithromycin
- Rifampin
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.