Vorapaxar and Clarithromycin Interaction
Drug interaction information between Vorapaxar and Clarithromycin.
Vorapaxar and Clarithromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vorapaxar and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin stops your body from processing vorapaxar correctly, leading to higher amounts of the drug in your blood.
FDA Label Information
Strong CYP3A Inhibitors Avoid concomitant use of ZONTIVITY with strong inhibitors of CYP3A (e.g., ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, boceprevir, telaprevir, telithromycin and conivaptan) [see Warnings and Precautions (5.2) and Clinical Pharmacology (12.3) ] .
Vorapaxar Also Interacts With
- Ketoconazole moderate
- Carbamazepine moderate
- Rifampin moderate
- Posaconazole moderate
- Itraconazole moderate
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Vorapaxar + Clarithromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Vorapaxar's 8. In the moderate band specifically: Vorapaxar has 7 (also Ketoconazole, Carbamazepine, Rifampin, Posaconazole); Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate).
What mechanism field is on file for Vorapaxar and Clarithromycin?
Clarithromycin stops your body from processing vorapaxar correctly, leading to higher amounts of the drug in your blood.
Clarithromycin carries more major-labeled pairs than Vorapaxar
SPL source-record counts only. This page's band is moderate · classes on file: Vorapaxar (PAR-1 Antagonist (Antiplatelet)); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Vorapaxar's 0. This page itself is in the moderate band, not the major band.
0 major · 7 moderate · 1 minor · 8 total
- Other moderate peers for Vorapaxar
- Ketoconazole
- Carbamazepine
- Rifampin
- Posaconazole
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.