Vorapaxar and Posaconazole Interaction
Drug interaction information between Vorapaxar and Posaconazole.
Vorapaxar and Posaconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vorapaxar and Posaconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Posaconazole interferes with the way your body clears vorapaxar, which can lead to an unsafe buildup of the medication.
FDA Label Information
Strong CYP3A Inhibitors Avoid concomitant use of ZONTIVITY with strong inhibitors of CYP3A (e.g., ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, boceprevir, telaprevir, telithromycin and conivaptan) [see Warnings and Precautions (5.2) and Clinical Pharmacology (12.3) ] .
Vorapaxar Also Interacts With
- Ketoconazole moderate
- Carbamazepine moderate
- Clarithromycin moderate
- Rifampin moderate
- Itraconazole moderate
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
Frequently Asked Questions
What SPL severity band is on file for Vorapaxar + Posaconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Posaconazole has 27 labeled pairs on file vs Vorapaxar's 8. In the moderate band specifically: Vorapaxar has 7 (also Ketoconazole, Carbamazepine, Clarithromycin, Rifampin); Posaconazole has 5 (also Efavirenz, Lovastatin, Suvorexant, Tacrolimus Topical).
What mechanism field is on file for Vorapaxar and Posaconazole?
Posaconazole interferes with the way your body clears vorapaxar, which can lead to an unsafe buildup of the medication.
Posaconazole carries more major-labeled pairs than Vorapaxar
SPL source-record counts only. This page's band is moderate · classes on file: Vorapaxar (PAR-1 Antagonist (Antiplatelet)); Posaconazole (Azole Antifungal).
Posaconazole has 5 major-labeled pairs vs Vorapaxar's 0. This page itself is in the moderate band, not the major band.
0 major · 7 moderate · 1 minor · 8 total
- Other moderate peers for Vorapaxar
- Ketoconazole
- Carbamazepine
- Clarithromycin
- Rifampin
5 major · 5 moderate · 17 minor · 27 total
- Other moderate peers for Posaconazole
- Efavirenz
- Lovastatin
- Suvorexant
- Tacrolimus Topical
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.