Vorapaxar and Rifampin Interaction
Drug interaction information between Vorapaxar and Rifampin.
Vorapaxar and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vorapaxar and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes your body to break down vorapaxar too quickly, which may prevent the medicine from working as it should.
FDA Label Information
Strong CYP3A Inducers Avoid concomitant use of ZONTIVITY with strong inducers of CYP3A (e.g., rifampin, carbamazepine, St.
Vorapaxar Also Interacts With
- Ketoconazole moderate
- Carbamazepine moderate
- Clarithromycin moderate
- Posaconazole moderate
- Itraconazole moderate
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Vorapaxar + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Vorapaxar's 8. In the moderate band specifically: Vorapaxar has 7 (also Ketoconazole, Carbamazepine, Clarithromycin, Posaconazole); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Vorapaxar and Rifampin?
Rifampin causes your body to break down vorapaxar too quickly, which may prevent the medicine from working as it should.
Rifampin carries more major-labeled pairs than Vorapaxar
SPL source-record counts only. This page's band is moderate · classes on file: Vorapaxar (PAR-1 Antagonist (Antiplatelet)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Vorapaxar's 0. This page itself is in the moderate band, not the major band.
0 major · 7 moderate · 1 minor · 8 total
- Other moderate peers for Vorapaxar
- Ketoconazole
- Carbamazepine
- Clarithromycin
- Posaconazole
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.