Vancomycin and Amphotericin B Interaction
Drug interaction information between Vancomycin and Amphotericin B.
Vancomycin and Amphotericin B have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vancomycin and Amphotericin B. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can be harmful to the kidneys when used at the same time.
FDA Label Information
Monitor renal function in patients receiving vancomycin and concurrent and/or sequential systemic or topical use of other potentially, neurotoxic and/or nephrotoxic drugs, such as amphotericin B, aminoglycosides, bacitracin, polymyxin B, colistin, viomycin, or cisplatin.
Vancomycin Also Interacts With
- Cidofovir major
- Colistin minor
- Piperacillin/Tazobactam minor
- Rosiglitazone minor
- Trospium minor
Amphotericin B Also Interacts With
- Cidofovir major
- Ganciclovir moderate
- Valganciclovir moderate
- Ketoconazole minor
- Anidulafungin minor
Frequently Asked Questions
What SPL severity band is on file for Vancomycin + Amphotericin B?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amphotericin B has 12 labeled pairs on file vs Vancomycin's 6. In the minor band specifically: Vancomycin has 5 (also Colistin, Piperacillin/Tazobactam, Rosiglitazone, Trospium); Amphotericin B has 9 (also Ketoconazole, Anidulafungin, Dexamethasone, Dronabinol).
What mechanism field is on file for Vancomycin and Amphotericin B?
Both of these medicines can be harmful to the kidneys when used at the same time.
Amphotericin B's labeled portfolio outnumbers Vancomycin
SPL source-record counts only. This page's band is minor · classes on file: Vancomycin (Glycopeptide Antibiotic); Amphotericin B (Polyene Antifungal).
1 major · 0 moderate · 5 minor · 6 total
- Other minor peers for Vancomycin
- Colistin
- Piperacillin/Tazobactam
- Rosiglitazone
- Trospium
1 major · 2 moderate · 9 minor · 12 total
- Other minor peers for Amphotericin B
- Ketoconazole
- Anidulafungin
- Dexamethasone
- Dronabinol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.