Vancomycin and Trospium Interaction
Drug interaction information between Vancomycin and Trospium.
Vancomycin and Trospium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vancomycin and Trospium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines are cleared out of the body by the same part of the kidneys. Taking them together might change how much of each drug stays in your system.
FDA Label Information
7.2 Drugs Eliminated by Active Tubular Secretion Although demonstrated in a drug-drug interaction study not to affect the pharmacokinetics of digoxin, trospium chloride tablets has the potential for pharmacokinetic interactions with other drugs that are eliminated by active tubular secretion (e.g., procainamide, pancuronium, morphine, vancomycin, and tenofovir).
Vancomycin Also Interacts With
- Cidofovir major
- Colistin minor
- Amphotericin B minor
- Piperacillin/Tazobactam minor
- Rosiglitazone minor
Trospium Also Interacts With
View all Trospium interactions →Frequently Asked Questions
What SPL severity band is on file for Vancomycin + Trospium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Vancomycin has 6 labeled pairs on file vs Trospium's 4. In the minor band specifically: Vancomycin has 5 (also Colistin, Amphotericin B, Piperacillin/Tazobactam, Rosiglitazone); Trospium has 4 (also Metformin, Morphine, Digoxin).
What mechanism field is on file for Vancomycin and Trospium?
These medicines are cleared out of the body by the same part of the kidneys. Taking them together might change how much of each drug stays in your system.
Vancomycin carries more major-labeled pairs than Trospium
SPL source-record counts only. This page's band is minor · classes on file: Vancomycin (Glycopeptide Antibiotic); Trospium (Anticholinergic (Overactive Bladder)).
Vancomycin has 1 major-labeled pair vs Trospium's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 5 minor · 6 total
- Other minor peers for Vancomycin
- Colistin
- Amphotericin B
- Piperacillin/Tazobactam
- Rosiglitazone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.