Vancomycin and Rosiglitazone Interaction
Drug interaction information between Vancomycin and Rosiglitazone.
Vancomycin and Rosiglitazone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vancomycin and Rosiglitazone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications compete for the same disposal path in the kidneys, which could potentially affect how they are cleared from your body.
FDA Label Information
[See Clinical Pharmacology (12.4).] 7.2 Cationic Drugs Although drug interactions for metformin with cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin) remain theoretical (except for cimetidine), careful patient monitoring and dose adjustment of AVANDAMET and/or the interfering drug is recommended in patients who are taking cationic medications that are excreted via the proximal renal tubular secretory system.
Vancomycin Also Interacts With
- Cidofovir major
- Colistin minor
- Amphotericin B minor
- Piperacillin/Tazobactam minor
- Trospium minor
Rosiglitazone Also Interacts With
- Clarithromycin major
- Metformin minor
- Morphine minor
- Amiloride minor
- Digoxin minor
Frequently Asked Questions
What SPL severity band is on file for Vancomycin + Rosiglitazone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosiglitazone has 12 labeled pairs on file vs Vancomycin's 6. In the minor band specifically: Vancomycin has 5 (also Colistin, Amphotericin B, Piperacillin/Tazobactam, Trospium); Rosiglitazone has 11 (also Metformin, Morphine, Amiloride, Digoxin).
What mechanism field is on file for Vancomycin and Rosiglitazone?
These medications compete for the same disposal path in the kidneys, which could potentially affect how they are cleared from your body.
Rosiglitazone's labeled portfolio outnumbers Vancomycin
SPL source-record counts only. This page's band is minor · classes on file: Vancomycin (Glycopeptide Antibiotic); Rosiglitazone (Thiazolidinedione).
1 major · 0 moderate · 5 minor · 6 total
- Other minor peers for Vancomycin
- Colistin
- Amphotericin B
- Piperacillin/Tazobactam
- Trospium
1 major · 0 moderate · 11 minor · 12 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.