Vancomycin and Piperacillin/Tazobactam Interaction
Drug interaction information between Vancomycin and Piperacillin/Tazobactam.
Vancomycin and Piperacillin/Tazobactam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vancomycin and Piperacillin/Tazobactam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two antibiotics together can increase the risk of sudden damage to your kidneys.
FDA Label Information
( 7.2 ) • Co-administration of ZOSYN with vancomycin may increase the incidence of acute kidney injury. Monitor kidney function in patients receiving ZOSYN and vancomycin. 7.3 Vancomycin Studies have detected an increased incidence of acute kidney injury in patients concomitantly administered piperacillin and tazobactam and vancomycin as compared to vancomycin alone [see Warnings and Precautions (5.6) ] .
Vancomycin Also Interacts With
- Cidofovir major
- Colistin minor
- Amphotericin B minor
- Rosiglitazone minor
- Trospium minor
Piperacillin/Tazobactam Also Interacts With
- Probenecid moderate
- Methotrexate minor
- Gentamicin minor
- Tobramycin minor
- Amikacin minor
Frequently Asked Questions
What SPL severity band is on file for Vancomycin + Piperacillin/Tazobactam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Piperacillin/Tazobactam has 7 labeled pairs on file vs Vancomycin's 6. In the minor band specifically: Vancomycin has 5 (also Colistin, Amphotericin B, Rosiglitazone, Trospium); Piperacillin/Tazobactam has 6 (also Methotrexate, Gentamicin, Tobramycin, Amikacin).
What mechanism field is on file for Vancomycin and Piperacillin/Tazobactam?
Taking these two antibiotics together can increase the risk of sudden damage to your kidneys.
Vancomycin carries more major-labeled pairs than Piperacillin/Tazobactam
SPL source-record counts only. This page's band is minor · classes on file: Vancomycin (Glycopeptide Antibiotic); Piperacillin/Tazobactam (Penicillin / Beta-Lactamase Inhibitor).
Vancomycin has 1 major-labeled pair vs Piperacillin/Tazobactam's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 5 minor · 6 total
- Other minor peers for Vancomycin
- Colistin
- Amphotericin B
- Rosiglitazone
- Trospium
0 major · 1 moderate · 6 minor · 7 total
- Other minor peers for Piperacillin/Tazobactam
- Methotrexate
- Gentamicin
- Tobramycin
- Amikacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.