Rivaroxaban and Clopidogrel Interaction
Drug interaction information between Rivaroxaban and Clopidogrel.
Rivaroxaban and Clopidogrel have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rivaroxaban and Clopidogrel. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs work to prevent blood clots, so taking them together makes it much easier for you to bleed.
FDA Label Information
7.4 Anticoagulants and NSAIDs/Aspirin Coadministration of enoxaparin, warfarin, aspirin, clopidogrel and chronic NSAID use may increase the risk of bleeding [see Clinical Pharmacology (12.3) ].
Rivaroxaban Also Interacts With
- Aspirin moderate
- Warfarin moderate
- Ketoconazole moderate
- Carbamazepine moderate
- Erythromycin moderate
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Frequently Asked Questions
What SPL severity band is on file for Rivaroxaban + Clopidogrel?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clopidogrel has 19 labeled pairs on file vs Rivaroxaban's 14. In the moderate band specifically: Rivaroxaban has 13 (also Aspirin, Warfarin, Ketoconazole, Carbamazepine); Clopidogrel has 9 (also Omeprazole, Warfarin, Esomeprazole, Rifampin).
What mechanism field is on file for Rivaroxaban and Clopidogrel?
Both drugs work to prevent blood clots, so taking them together makes it much easier for you to bleed.
Clopidogrel's labeled portfolio outnumbers Rivaroxaban
SPL source-record counts only. This page's band is moderate · classes on file: Rivaroxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Clopidogrel (Antiplatelet Agent).
0 major · 13 moderate · 1 minor · 14 total
- Other moderate peers for Rivaroxaban
- Aspirin
- Warfarin
- Ketoconazole
- Carbamazepine
0 major · 9 moderate · 10 minor · 19 total
- Other moderate peers for Clopidogrel
- Omeprazole
- Warfarin
- Esomeprazole
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.