Rivaroxaban and Aspirin Interaction
Drug interaction information between Rivaroxaban and Aspirin.
Rivaroxaban and Aspirin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rivaroxaban and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two medicines at the same time increases the risk of bleeding because they both interfere with how blood clots.
FDA Label Information
7.4 Anticoagulants and NSAIDs/Aspirin Coadministration of enoxaparin, warfarin, aspirin, clopidogrel and chronic NSAID use may increase the risk of bleeding [see Clinical Pharmacology (12.3) ]. Promptly evaluate any signs or symptoms of blood loss if patients are treated concomitantly with aspirin, other platelet aggregation inhibitors, or NSAIDs [see Warnings and Precautions (5.2) ] .
Rivaroxaban Also Interacts With
- Clopidogrel moderate
- Warfarin moderate
- Ketoconazole moderate
- Carbamazepine moderate
- Erythromycin moderate
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Rivaroxaban + Aspirin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Rivaroxaban's 14. In the moderate band specifically: Rivaroxaban has 13 (also Clopidogrel, Warfarin, Ketoconazole, Carbamazepine); Aspirin has 12 (also Alendronate, Apixaban, Desvenlafaxine, Dexamethasone).
What mechanism field is on file for Rivaroxaban and Aspirin?
Using these two medicines at the same time increases the risk of bleeding because they both interfere with how blood clots.
Aspirin carries more major-labeled pairs than Rivaroxaban
SPL source-record counts only. This page's band is moderate · classes on file: Rivaroxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Rivaroxaban's 0. This page itself is in the moderate band, not the major band.
0 major · 13 moderate · 1 minor · 14 total
- Other moderate peers for Rivaroxaban
- Clopidogrel
- Warfarin
- Ketoconazole
- Carbamazepine
3 major · 12 moderate · 32 minor · 47 total
- Other moderate peers for Aspirin
- Alendronate
- Apixaban
- Desvenlafaxine
- Dexamethasone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.