What the FDA labels say about taking them together
Aspirin and rivaroxaban
Rivaroxaban's FDA label of September 10, 2026 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name rivaroxaban. The rivaroxaban label: “Coadministration of enoxaparin, warfarin, aspirin, clopidogrel and chronic NSAID use may increase the risk of bleeding.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the rivaroxaban FDA label on DailyMed (effective September 10, 2026, Janssen Pharmaceuticals, Inc.).
What does the aspirin label say about rivaroxaban?
Aspirin's label (effective September 9, 2025) does not name rivaroxaban in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the rivaroxaban label say about aspirin?
Rivaroxaban label, drug interactionsCoadministration of enoxaparin, warfarin, aspirin, clopidogrel and chronic NSAID use may increase the risk of bleeding [see Clinical Pharmacology (12.3) ].
Rivaroxaban label, warnings and precautionsThese include aspirin, P2Y 12 platelet inhibitors, dual antiplatelet therapy, other antithrombotic agents, fibrinolytic therapy, non-steroidal anti-inflammatory drugs (NSAIDs) [see Drug Interactions (7.4) ], selective serotonin reuptake inhibitors, and serotonin norepinephrine reuptake inhibitors.
Source: FDA drug label (Xarelto), Janssen Pharmaceuticals, Inc., effective September 10, 2026 (SPL set 10db92f9-2300-4a80-836b-673e1ae91610), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Rivaroxaban | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Atrial fibrillation, Heart attack and coronary artery disease, Blood clots (DVT and PE), Stroke prevention |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.650 per tablet 2.5 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once